Telomere-associated protein RIF1 is a protein that in humans is encoded by the RIF1 gene.[5][6][7]
RIF1 and RIF2 cap the chromosome ends (telomeres) in yeast.[8] In higher eukaryotes, Rif1 is involved in DNA damage response, organisation of chromatin architecture and the regulation of replication timing. RIF1 has been shown to bind to RNA in the nucleus.[9]