| Rank | Name | State | Pop. | Rank | Name | State | Pop. | ||
|---|---|---|---|---|---|---|---|---|---|
 Valley of Mexico  Monterrey |
1 | Valley of Mexico | Mexico City, State of Mexico, Hidalgo | 21,804,515 | 11 | Aguascalientes | Aguascalientes | 1,225,432 | .jpg) Guadalajara  Puebla–Tlaxcala |
| 2 | Monterrey | Nuevo León | 5,341,171 | 12 | San Luis Potosí | San Luis Potosí | 1,221,526 | ||
| 3 | Guadalajara | Jalisco | 5,286,642 | 13 | Mérida | Yucatán | 1,201,000 | ||
| 4 | Puebla–Tlaxcala | Puebla, Tlaxcala | 3,199,530 | 14 | Mexicali | Baja California | 1,031,779 | ||
| 5 | Toluca | State of Mexico | 2,353,924 | 15 | Saltillo | Coahuila | 1,031,779 | ||
| 6 | Tijuana | Baja California | 2,157,853 | 16 | Cuernavaca | Morelos | 1,028,589 | ||
| 7 | León | Guanajuato | 1,924,771 | 17 | Culiacán | Sinaloa | 1,003,530 | ||
| 8 | Querétaro | Querétaro | 1,594,212 | 18 | Morelia | Michoacán | 988,704 | ||
| 9 | Juárez | Chihuahua | 1,512,450 | 19 | Chihuahua | Chihuahua | 988,065 | ||
| 10 | La Laguna | Coahuila, Durango | 1,434,283 | 20 | Veracruz | Veracruz | 939,046 | ||