The Great Deceiver may refer to:

• Satan, an embodiment of antagonism in Abrahamic beliefs
• The Great Deceiver (band), a Swedish hardcore/metal band
• The Great Deceiver (King Crimson album), a 1992 box set
• The Great Deceiver (Mortiis album) a forthcoming album by Mortiis
• The Great Deceiver (1953 film), a Mexican film
• "The Great Deceiver", a song by Evergrey from Recreation Day
• "The Great Deceiver", a song by In Flames from Foregone
• "The Great Deceiver", a song by King Crimson from Starless and Bible Black