Sharon and the dogs are in the backyard. Lola the bulldog then vomits on the grass. Ozzy then tries to show off his knife throwing skills by trying to throw knives into logs. As Jack is in the car going somewhere he makes a call saying there are fans on the lawn and the sprinklers should be turned on to scare them away. Sharon then shows Melinda a gold filling that she had accidentally swallowed.

Ozzy then announces that he and Sharon have been invited to Washington DC for a press dinner at the White House. Ozzy doesn't know how to handle it and he doesn't know proper etiquette, he's a street guy. Sharon helps Ozzy pick out a watch to wear.

Jack then announces that Kelly has covered Madonna's "Papa Don't Preach" and that she would be singing it at the MTV Movie Awards. This leads to a scene of Ozzy dancing with Kelly while the song plays in the background. Jack then tells us that he had a part in Kelly getting signed to a record contract and Kelly discusses that she doesn't want a chick band.

Ozzy and Sharon leave to go to Washington and Sharon tells Ozzy that she got President Bush some cuff-links as a gift. Ozzy asks how is she going to give The President a gift. Ozzy says that he's the President...he's not allowed to accept gifts. They arrive in Washington and drive past the Washington Monument and Lincoln Monument. Sharon admits that she doesn't know who President Bush is and that Ozzy is starting to get stage fright.

Back home, Jack continues his playful attitude with fans and the sprinklers. Kelly then goes to rehearsal and she steals Jack's spritz bottle. Jack tells Kelly, "Just because you have a hit song doesn't mean you can steal my spritz bottle."

Back in Washington, Ozzy and Sharon are getting ready for their dinner and Sharon says that Ozzy looks like Harrison Ford. Ozzy says he looks more like Glenn Close. He then calls Sharon a cunt, but then quickly apologizes. He then looks into the camera and says, "I found out you can say anything to a woman. But you mention the "C" word and you suddenly get this feeling of death come over you." At the dinner President Bush says, "What a fantastic audience we have tonight. Washington power brokers, celebrities, Hollywood stars, Ozzy Osbourne." Then causes Ozzy to stand up with a big smile on his face and the crowd applauds him.

Ozzy then flies to England and Sharon joins Kelly and Jack. At the movie awards, all the attention goes to Kelly, while Jack is on a quest to find Natalie Portman. Ozzy introduces Kelly and she does a great performance. That night on the ride home they pass a McDonald's and Jack is happy to see that the McRib is back. This irks Kelly and he tells Kelly that it's the little things in life that make people happy.

Sharon recuperates at the family's Malibu beach house while undergoing treatment for colon cancer. She vows to beat the disease, and tries to maintain as normal a life as possible. Everyone talks about their reactions to the news of her diagnosis. Ozzy struggles to remain sober while on tour with Ozzfest. He had already been going through detox, and the news of Sharon's illness has made a difficult situation much worse.

Kelly travels to Europe for a series of interviews and appearances. She is upset when her bag is lost (apparently seized by security because of concerns over her gun-shaped pin), leaving her without any extra underwear. She first visits Germany, where she deals with several adoring fans and tries to fake her way through a radio interview conducted in German ("That's amazing. I always don't know what to say"). Kelly then goes to England to perform "Papa Don't Preach" on Top of the Pops. Jack heads to North Carolina to film a guest spot for Dawson's Creek.

Kelly begins dating Bert McCracken, lead singer of the band The Used. Sharon worries after hearing some stories about Bert ("They call him cauliflower dick. Cauliflower dick!? Don't you get that from Virg-, Virginia, Virginial, Venereal disease mum. Venereal disease! Why do I keep thinking fucking Virginial?"), while Jack thinks that Bert is weird because he professed his love to Kelly after only a few weeks of dating. Kelly warns that she will run off to Vegas and marry before the end of the year. Sharon actually encourages this, saying that she needs some excitement. Sharon worries about the situation, but Ozzy encourages her to relax and just focus on living one day at a time.

Sharon makes amends with her father after not speaking with him for over twenty years. Kelly keeps going out and getting drunk every night, despite Sharon's pleas. Ozzy tries to warn her of the consequences of her actions, as they can't protect her if she gets arrested for underage drinking. Pop star Mandy Moore comes over to the house to hang out with Jack.

Kelly recruits her friend Sarah to play the drums in her band. However, Sarah has never had any formal lessons, and can't seem to keep up with the others during rehearsals. Everyone becomes very frustrated, and reaches the conclusion that Sarah must be replaced by someone with more experience. Kelly can't bring herself to fire her friend, so Sharon volunteers to handle it. Sarah gets $10,000 for her services, and a job handling the slate during the filming of Kelly's video for "Shut Up."

Kelly grows frustrated with all of the appearances she must make as a recording artist. She yells and screams at everyone. Sharon sympathizes with her, noting that she just wants to be a teenager and is having a hard time handling all of the demands being placed on her. She asks Ozzy to go talk to Kelly and reassure her. Kelly quickly sends him scampering away as she throws a screaming fit. Kelly flies to New York to work on her album. She does a photo shoot for Vanity Fair, and ends up storming off and having another tantrum.

Ozzy grows increasingly tired of the dogs and their tendency to defecate in the house. Because Sharon's immune system is very weak due to the chemo, he fears that all of the germs will cause her to develop an infection. He constantly cleans everything and tries to get everyone to wear gloves around Sharon. He also urges Sharon not to let the dogs on the bed, but she ignores him. Ozzy meets with a contractor about plans to build an outdoor kennel for all of the dogs, but Sharon quickly kills this idea.

The Osbournes pack their bags for Sin City as Ozzy prepares for a concert and Kelly celebrates her 18th birthday. Before heading to Vegas, Kelly discovers that she has been made to sign a contract with The Venetian Resort Hotel Casino as the hotel clearly states that if anyone is seen to be drinking underage, then they would all be thrown out of the hotel.

Sharon and Ozzy decide to renew their wedding vows at a hotel on New Year's Eve. Kelly is to serve as flower girl, with Jack and Robert as ushers. Kelly objects to the fact that the ceremony will be conducted by a rabbi; although Sharon's father is Jewish, Kelly insists that a person cannot be Jewish unless their mother is (Sharon: "Excuse me, my husband is circumcised"). Ozzy is not at all enthused about the ceremony. Kelly and Sarah are less than impressed with Jack's latest female "friend," particularly because she once dated Jack's best friend.

Sharon catches the girl in bed with Jack, and later finds condoms in the room. She tries to encourage Jack to settle down and find a steady girlfriend, but he would rather juggle several girls because the idea of a relationship freaks him out. Ozzy and Jack have various body parts plucked, shaved and waxed before the wedding. Sharon recalls the couple's first wedding night, when Ozzy passed out drunk in the hallway.

The Osbournes struggle to come up with a gift for Jack's birthday. Kelly strongly objects when Jack dances with Christina Aguilera, whom Kelly had previously insulted on a number of occasions. Kelly complains that Jack is disrespecting her by hanging around someone that she dislikes, and insists that she would never do this to Jack. Jack tries to explain that Christina actually had nice things to say about Kelly. The kids get into a brawl, which Sharon must break up.

The pets suffer from a flea infestation, creating havoc around the house and leaving everyone itchy and miserable. Kelly prepares to go on a trip to Philadelphia to visit her boyfriend, Bert. Sharon does not want her to go away alone (she prefers her to have security at all times), and drives Kelly crazy as she somewhat jokingly nags her. Sharon has Robert and Jack move a heavy statue out to the garden, but never seems satisfied by the location. She forces them to move it several times.

Ozzy and Sharon prepare to leave for a few days on a Hawaiian vacation. Ozzy tells Jack that he is no longer to have people over at the house after 11 PM. Kelly is afraid that Jack will turn the house into a nonstop party while their parents are gone. Sharon promises to talk to him, but this does little to reassure Kelly. Jack has a lot of people over late at night, and they soon begin using the pool and making a lot of noise.

Kelly becomes very upset because she is tired of Jack and his friends keeping her from sleeping. He refuses to listen to Melinda when she asks them to be quiet. When Kelly confronts Jack, he dares her to hit him, so she nails him in the face. They get into a fight, and the staff has to pry them apart. Kelly calls Sharon for sympathy, but Jack gets on the line and complains about the cuts to the face he sustained from the punch.

Sharon receives a peace offering from one of her folk-singing neighbors, but the neighbors on the other side begin to drive the family crazy by playing tennis at all hours of the day and night. Jack tries playing drums outside, and Ozzy blasts the loudest, most obnoxious music he can find. However, nothing seems to have an effect on the neighbors.

Jack and Robert fly to England to spend time at the Osbournes' other home. Jack shows Robert the house and introduces him to the family's oldest dog, Sugar. Some of Jack's friends also come over to hang out with them and drink. Lola grows lonely and bored because she misses Jack so much. Sharon also laments the departures of both Jack and Kelly, who is away on tour.

Kelly experiences problems in her relationship with Bert. He finally breaks up with her over the phone on Valentine's Day, claiming that no one took him seriously because he was dating her. Kelly becomes extremely irritable and depressed, and takes her anger out on the family. She argues with Sharon, who suggests that she find another manager; and bites Jack on the arm. She overhears her family talking about her and decides to leave home.

Meanwhile, Jack is alarmed when he acts out violently in his sleep. He wakes up one night to find himself beating up Lola. On another night, he attacks Minnie; and is horrified to wake up and discover that he has killed her. He flees the house with the body. A devastated Sharon retreats to the family's Malibu home to escape memories of Minnie.