Thialbarbital
Thialbarbital.svg
Clinical data
Other namesKemithal, 5-(1-cyclohex-2-enyl)-5-prop-2-enyl-2-sulfanylidene-1,3-diazinane-4,6-dione
ATC code
  • none
Legal status
Legal status
Identifiers
  • 5-allyl-5-cyclohex-2-en-1-yl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
ECHA InfoCard100.006.720 Edit this at Wikidata
Chemical and physical data
FormulaC13H16N2O2S
Molar mass264.34 g·mol−1
3D model (JSmol)
  • O=C1NC(=S)NC(=O)C1(C2/C=C\CCC2)C\C=C
  • InChI=1S/C13H16N2O2S/c1-2-8-13(9-6-4-3-5-7-9)10(16)14-12(18)15-11(13)17/h2,4,6,9H,1,3,5,7-8H2,(H2,14,15,16,17,18) checkY
  • Key:PXLVRFQEBVNJOH-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Thialbarbital (Intranarcon) is a barbiturate derivative invented in the 1960s. It has sedative effects, and was used primarily for induction in surgical anaesthesia.[1] Thialbarbital is short acting and has less of a tendency to induce respiratory depression than other barbiturate derivatives such as pentobarbital.[2]

Synthesis

Thialbarbital synthesis: Volwiler, Tabern, U.S. Patent 2,153,730 (1939 to Abbott)
Thialbarbital synthesis: Volwiler, Tabern, U.S. Patent 2,153,730 (1939 to Abbott)

See also

References

  1. ^ Golovchinsky VB, Plehotkina SI (July 1971). "Difference in the sensitivity of the cerebral cortex and midbrain reticular formation to the action of diethylether and thialbarbital". Brain Research. 30 (1): 37–47. doi:10.1016/0006-8993(71)90004-7. PMID 5092630.
  2. ^ Bercovitz AB, Godke RA, Biellier HV, Short CE (March 1975). "Surgical anesthesia in turkeys with thialbarbital sodium". American Journal of Veterinary Research. 36 (3): 301–2. PMID 1115429.