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Thiomescaline (TM) is a pair of lesser-known psychedelic drugs with the molecular formula C11H17NO2S. 3-TM and 4-TM are analogs of mescaline in which an oxygen atom has been replaced with a sulfur atom. They were first synthesized by Alexander Shulgin and described in his book PiHKAL.[1][2] Very little data exists on the pharmacological properties, metabolism, and toxicity of thiomescaline.[citation needed]


3-TM, or 3-methylthio-4,5-dimethoxyphenethylamine
3-TM, or 3-methylthio-4,5-dimethoxyphenethylamine

Dosage: 60–100 mg

Duration: 8–12 hours

Effects: strong open and closed-eye visuals, synesthesia upon listening to music, +++ on the Shulgin Rating Scale


4-TM, or 4-methylthio-3,5-dimethoxy-phenethylamine
4-TM, or 4-methylthio-3,5-dimethoxy-phenethylamine

Dosage: 20–40 mg

Duration: 10–15 hours

Effects: LSD-like imagery and effects

See also