Thonzonium bromide
Names
Preferred IUPAC name
N-(2-{[(4-Methoxyphenyl)methyl](pyrimidin-2-yl)amino}ethyl)-N,N-dimethylhexadecan-1-aminium bromide
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.008.212 Edit this at Wikidata
UNII
  • InChI=1S/C32H55N4O.BrH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-27-36(2,3)28-26-35(32-33-24-19-25-34-32)29-30-20-22-31(37-4)23-21-30;/h19-25H,5-18,26-29H2,1-4H3;1H/q+1;/p-1 checkY
    Key: WBWDWFZTSDZAIG-UHFFFAOYSA-M checkY
  • [Br-].O(c1ccc(cc1)CN(c2ncccn2)CC[N+](CCCCCCCCCCCCCCCC)(C)C)C
Properties
C32H55BrN4O
Molar mass 591.723 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Thonzonium bromide is a monocationic detergent.[1] A solution of it is thus a surfactant and a detergent that promotes tissue contact by dispersion and penetration of the cellular debris and exudate of the containing solution.[2]

It is used in cortisporin-TC ear drops to help penetration of active ingredients through cellular debris for its antibacterial action.[3][4]

References

  1. ^ "Thonzonium bromide". Long Island University. Retrieved 2023-01-02.
  2. ^ "Otic Antibiotics Review 2009" (PDF). Otic Antibiotics Review. 6 (1): 11. 2009-12-15. Archived (PDF) from the original on 2023-01-03. Retrieved 2023-01-03 – via Nevada Department of Health and Human Services.
  3. ^ "Cortisporin-TC: Indications, Side Effects, Warnings". Drugs.com. 2022-10-15. Archived from the original on 2023-01-03. Retrieved 2023-01-03.
  4. ^ "CORTISPORIN-TC- colistin sulfate, neomycin sulfate, thonzonium bromide and hydrocortisone acetate suspension" (PDF). Food and Drug Administration. 2019. Archived (PDF) from the original on 2023-01-03. Retrieved 2023-01-02.
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