TRHR
Identifiers
Aliases	TRHR, TRH-R, thyrotropin releasing hormone receptor, CHNG7
External IDs	OMIM: 188545 MGI: 98824 HomoloGene: 20707 GeneCards: TRHR
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q23.1 Start 109,086,585 bp[1] End 109,121,565 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 B3.2|15 16.82 cM Start 44,059,531 bp[2] End 44,099,308 bp[2]
RNA expression pattern Bgee Top expressed in Achilles tendon pituitary gland anterior pituitary corpus callosum prosencephalon thyroid gland gastrocnemius muscle left ventricle brain More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity thyrotropin-releasing hormone receptor activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process signal transduction G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7201	22045
Ensembl	ENSG00000174417	ENSMUSG00000038760
UniProt	P34981	P21761
RefSeq (mRNA)	NM_003301	NM_013696
RefSeq (protein)	NP_003292	NP_038724
Location (UCSC)	Chr 8: 109.09 – 109.12 Mb	Chr 15: 44.06 – 44.1 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Thyrotropin-releasing hormone receptor (TRHR) is a G protein-coupled receptor which binds thyrotropin-releasing hormone.^[5][6]

The TRHR is found on the cell membrane of thyrotropes of the anterior pituitary. When the TRHR binds TRH it activates phospholipase C, which causes the formation of inositol triphosphate (IP3) and diacylglycerol (DAG). This leads to an increase in cytoplasmic calcium ion concentrations which stimulates the exocytosis of thyroid-stimulating hormone (TSH) into the blood.