Tibotec
IndustryPharmaceutical
Founded1994; 30 years ago (1994)
Founders
  • Rudi Pauwels
  • Carine Claeys
  • Marie-Pierre de Béthune
  • Kurt Hertogs
  • Hilde Azijn
Defunct2002 (2002)
FateAcquired by Johnson & Johnson and merged into its Janssen Pharmaceuticals division
Websitetibotec.com

Tibotec was a pharmaceutical company with a focus on research and development for the treatment of infectious diseases such as HIV/AIDS and hepatitis C. The company was founded in 1994 and then acquired by Johnson & Johnson and merged into its Janssen Pharmaceuticals division in 2002.

The name of the company is derived from the tetrahydro-imidazo[4,5,1-jk][1,4]-benzodiazepine-2(1H)-one and -thione (TIBO) compounds discovered at the Rega Institute for Medical Research (Belgium).[1]

History

In 1994, Rudi Pauwels of the Rega Institute for Medical Research founded Tibotec, together with his wife Carine Claeys, and their first co-workers Marie-Pierre de Béthune, Kurt Hertogs, and Hilde Azijn. In 1995 Paul Stoffels joined Tibotec. The company was acquired by Johnson & Johnson in April 2002,[2] and was renamed Janssen Therapeutics in June 2011.[3]

Tibotec provided funding for HIV treatment clinical trials at the Infectious Diseases Institute in Kampala, Uganda.[4][5]

Drugs

See also

References

  1. ^ Pauwels, Rudi; Andries, Koen; Desmyter, Jan; Schols, Dominique; Kukla, Michael J.; Breslin, Henry J.; Raeymaeckers, Alfons; Gelder, Jozef Van; Woestenborghs, Robert; Heykants, Jozef; Schellekens, Karel; Janssen, Marcel A. C.; Clercq, Erik De; Janssen, Paul A. J. (1990). "Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives". Nature. 343 (6257): 470–474. Bibcode:1990Natur.343..470P. doi:10.1038/343470a0. PMID 1689015. S2CID 4354080.
  2. ^ "Johnson & Johnson to Acquire Tibotec-Virco". Johnson & Johnson. 2002-03-22. Archived from the original on 2002-06-08. Retrieved 2023-05-16.((cite web)): CS1 maint: unfit URL (link)
  3. ^ Van Houten, Pamela (2011-06-22). "Tibotec Therapeutics Becomes Janssen Therapeutics, Part Of The Janssen Pharmaceutical Companies". Johnson & Johnson. Archived from the original on 2023-05-17. Retrieved 2023-05-17.
  4. ^ Schmickle, Sharon (2008-11-13). "University of Minnesota doctors battle AIDS in Uganda". MinnPost. Archived from the original on 2010-06-23. Retrieved 2023-05-16.((cite web)): CS1 maint: unfit URL (link)
  5. ^ "Clinical Research at the Infectious Diseases Institute" (PDF). The Global Health Network. Infectious Diseases Institute. Archived (PDF) from the original on 2023-05-17. Retrieved 2023-05-17.
  6. ^ Andries, K.; Verhasselt, P; Guillemont, J; Göhlmann, H. W.; Neefs, J. M.; Winkler, H; Van Gestel, J; Timmerman, P; Zhu, M; Lee, E; Williams, P; De Chaffoy, D; Huitric, E; Hoffner, S; Cambau, E; Truffot-Pernot, C; Lounis, N; Jarlier, V (2005). "A Diarylquinoline Drug Active on the ATP Synthase of Mycobacterium tuberculosis". Science. 307 (5707): 223–7. Bibcode:2005Sci...307..223A. doi:10.1126/science.1106753. PMID 15591164. S2CID 33219841.
  7. ^ Zeuzem S, Berg T, Gane E, et al. (2012). TMC435 in HCV Genotype 1 Patients Who Have Failed Previous Pegylated Interferon/Ribavirin Treatment: Final SVR24 Results of the ASPIRE Trial. 47th Annual Meeting of the European Association for the Study of the Liver. Barcelona, April 18–22, 2012. Abstract 2.

External links

Johnson & Johnson
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