16th–18th centuries
| History of Puerto Rico |
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 Puerto Rico portal |
- 1511 – First Catholic Diocese established in San Juan[2]
- 1521 – "Ciudad de San Juan Bautista de Puerto Rico" founded by Spanish colonists from nearby Caparra.[3][4]
- 1523 – Convento de Santo Tomas de Aquino founded.[5]
- 1524 – Nuestra Senora de la Concepcion hospital built.[5]
- 1526 – October 4: St. Francis Hurricane occurs.[3]
- 1529 – October 18: Harbor attack by Caribs.[5]
- 1530
- 1532 – San José Church construction begins.[6]
- 1540 – La Fortaleza built.[5]
- 1542 – Cathedral of San Juan Bautista construction begins.[7]
- 1560 – City wall construction begins.[3]
- 1560s – San Antonio Bridge built across Condado Lagoon.[5]
- 1568 – September 7: Hurricane occurs.[3]
- 1582 – Population: 850 (approximate estimate).[5]
- 1591 – Castillo San Felipe del Morro construction begins.[6]
- 1595 – November 22: Battle of San Juan begins.[5][4]
- 1598 – June: San Juan taken by British forces; Boquerón battery sacked.[3][4]
- 1605 – Cabildo constructed in Plaza de San Juan.[6]
- 1615 – September 12: Hurricane occurs.[3]
- 1625 – September 24: Town besieged by Dutch forces.[5]
- 1733 – Palacio Episcopal construction begins (approximate date).[7]
- 1769 – Powder house built.
- 1780 – Capilla del Santo Cristo de la Salud (chapel) built.[7]
- 1783 – Castillo de San Cristóbal built.[4]
- 1787
- May 2: 1787 Boricua earthquake.
- May 3: Fiesta de Cruz begins.[8]
- 1797 – April: San Juan besieged by British forces.[9][4]
