Lipase (class 3)
Structure of Triacyl-glycerol acylhydrolase.
Identifiers
Symbol	Lipase_3
Pfam	PF01764
InterPro	IPR002921
PROSITE	PDOC00110
SCOP2	3tgl / SCOPe / SUPFAM
OPM superfamily	127
OPM protein	3tgl
CDD	cd00519
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

The enzyme triacylglycerol lipase (also triglyceride lipase, EC 3.1.1.3;systematic name triacylglycerol acylhydrolase) catalyses the hydrolysis of ester linkages of triglycerides:^[1]

triacylglycerol + H₂O ⇌ diacylglycerol + a carboxylate

These lipases are widely distributed in animals, plants and prokaryotes. This family was also called class 3 lipases as they are only distantly related to other lipase families.^{[2][3][4][5][6]}

Human proteins containing this domain

DAGLA; DAGLB; LOC221955; The pancreatic enzyme acts only on an ester-water interface.

Nomenclature

Other names include lipase, butyrinase, tributyrinase, Tween hydrolase, steapsin, triacetinase, tributyrin esterase, Tweenase, amno N-AP, Takedo 1969-4-9, Meito MY 30, Tweenesterase, GA 56, capalase L, triglyceride hydrolase, triolein hydrolase, tween-hydrolyzing esterase, amano CE, cacordase, triglyceridase, triacylglycerol ester hydrolase, amano P, amano AP, PPL, glycerol-ester hydrolase, GEH, meito Sangyo OF lipase, hepatic lipase, lipazin, post-heparin plasma protamine-resistant lipase, salt-resistant post-heparin lipase, heparin releasable hepatic lipase, amano CES, amano B, tributyrase, triglyceride lipase, liver lipase, hepatic monoacylglycerol acyltransferase).