Trifluoromethoxy group

The trifluoromethoxy group is the chemical group –O–CF
. It can be seen as a methoxy group –O–CH
whose hydrogen atoms are replaced by fluorine atoms; or as a trifluoromethyl group attached to the rest of the molecule by a bridging oxygen atom; either leads to viable syntheses.[1] Compounds having this functional group are of some relevance as pharmaceuticals. One example is riluzole.

See also


  1. ^ Synthetic Approaches to Trifluoromethoxy-Substituted Compounds A. Tlili, F. Toulgoat, T. Billard, Angew. Chem. Int. Ed. 2016, 55, 11726–11735; doi:10.1002/anie.201603697