Tryphon, Triphon, or Trypho may refer to:

People

People of church

• Diodotus Tryphon (fl. 144–138 BC), Seleucid ruler
• Salvius Tryphon (fl. c. 100 BC), rebel slave
• Tryphon (grammarian) (c. 60 BC – 10 BC), Greek grammarian
• Tarfon (c. 100), Jewish rabbi
• Trypho (fl. 2nd century), Jewish philosopher in Dialogue with Trypho, possibly same as the rabbi
• Trypho (theologian) (fl. AD 240), Bible scholar
• Tryphon (Turkestanov) (1861–1934), hierarch of the Russian Orthodox Church
• Saint Tryphon (disambiguation), several saints

Other people

• Tryphon Kin-Kiey Mulumba (born 1949), Congolese politician
• Tryphon Samaras, Greek hairdresser and television personality
• Trifonas Nikolaidis [he] (born 1944), Cypriot-Israeli singer

Other

• Tryphon (play), a 1668 play by the Irish writer Roger Boyle
• Tryphon (wasp), a genus in the family Ichneumonidae
• Professor Calculus (French: Professeur Tryphon Tournesol), a fictional character in The Adventures of Tintin