| Tryptophan N-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.13.125 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Tryptophan N-monooxygenase (EC 1.14.13.125, tryptophan N-hydroxylase, CYP79B1, CYP79B2, CYP79B3) is an enzyme with systematic name L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating).[1][2][3][4] This enzyme catalyses the following chemical reaction
- L-tryptophan + 2 O2 + 2 NADPH + 2 H+ (E)-indol-3-ylacetaldoxime + 2 NADP+ + CO2 + 3 H2O (overall reaction)
- (1a) L-tryptophan + O2 + NADPH + H+ N-hydroxy-L-tryptophan + NADP+ + H2O
- (1b) N-hydroxy-L-tryptophan + O2 + NADPH + H+ N,N-dihydroxy-L-tryptophan + NADP+ + H2O
- (1c) N,N-dihydroxy-L-tryptophan (E)-indol-3-ylacetaldoxime + CO2 + H2O
Tryptophan N-monooxygenase is a heme-thiolate protein (P-450).
