Tyrwhitt-Drake is an English surname. Notable people with the surname include:

• Bill Tyrwhitt-Drake (1926–2008), English cricketer
• Edward Tyrwhitt Drake (1832–1904), English clergyman and cricketer
• Garrard Tyrwhitt-Drake (1881–1964), English businessman, zoo owner and author
• Montague Tyrwhitt-Drake (1830–1908), English-born lawyer, judge and political figure in Canada
• Thomas Drake Tyrwhitt-Drake (1749–1810), British Member of Parliament
• Thomas Tyrwhitt-Drake (1783–1852), British Member of Parliament
• Charles Francis Tyrwhitt-Drake (1846–1874), explorer, naturalist, archaeologist, and linguist who died during the PEF Survey of Palestine

Others

• Francis Tyrwhitt Drake Wilson (1876–1964), British cricketer
• Tyrwhitt-Drake Museum of Carriages in Tithe Barn, Maidstone