U.S. Highway 301
US 301 highlighted in red
Route information
Auxiliary route of US 1
Maintained by SCDOT
Length	189.704 mi[1][2][3][4][5][6][7] (305.299 km)
Existed	1948–present
Major junctions
South end	US 301 / SR 73 at the Georgia state line near Allendale
Major intersections	US 278 in Allendale US 321 in Ulmer US 21 / US 601 in Orangeburg I-26 near Orangeburg US 176 near Elloree I-95 / US 15 near Summerton US 521 in Manning US 378 in Turbeville US 52 in Effingham US 76 / SC 327 near Mars Bluff
North end	I-95 / US 301 / US 501 at the North Carolina state line near Hamer
Location
Country	United States
State	South Carolina
Counties	Allendale, Bamberg, Orangeburg, Clarendon, Florence, Marion, Dillon
Highway system
United States Numbered Highway System List Special Divided South Carolina State Highway System Interstate US State Scenic
← SC 300 → SC 302

U.S. Route 301 (US 301) is a 189.704-mile (305.299 km) U.S. Highway that travels north–south from the Savannah River southwest of Allendale to Hamer approaching the South of the Border roadside attraction complex.

Route description

US 301 enters South Carolina over the Savannah River southwest of Allendale. In Allendale, it has a short Concurrency with US 278. Additional concurrencies include US 321 in and around Ulmer, US 601 between Bamberg and Orangeburg, then US 15 and shortly afterwards Interstate 95 (I-95) in Santee, at exit 97 before all three move across Lake Marion. The US 15-301 concurrency leaves I-95 at exit 102, running in close proximity to I-95, but US 15 breaks away at Summerton, remaining on Church Street while US 301 turns right onto Main Street, which becomes Alvin Hardin Highway. Other concurrencies include US 521 from Manning to Alcolu, US 378 in Turbeville, US 52 between Effingham and just south of Florence, US 76 eastbound from east of Florence until Pee Dee, and finally joins US 501 in Latta, where they both approach the South of the Border roadside attraction complex at the interchange with I-95 on the North–South Carolina border.

History

US 301 was established in 1932 as a replacement of the piece of US 17-1 north of Wilson and the whole of US 217. Thus US 301 initially ran from US 17 (now US 76) at Pee Dee northeast through Dillon, South Carolina, into North Carolina, and Virginia, ending at U.S. Route 1 in Petersburg, Virginia.^{[citation needed]} This entire route is now paralleled by I-95.

In 1935, US 301 was extended southwest to US 15 at Summerton. This extension took it west on US 76 (formerly US 17) to Florence and south on US 52 (also formerly US 17) to Effingham. There it split to the southwest, running along what had been SC 4 via Manning to Summerton.^{[citation needed]} This again travels parallel to I-95.

In the late 1940s, US 301 was extended again, south all the way towards Tampa, Florida. On the way there from South Carolina it ran along US 15 southwest to Santee, South Carolina and replaced SC 4 west to Orangeburg. From Orangeburg, US 301 ran southwest with U.S. Route 601 to Bamberg, replaced SC 33 to Ulmer, replaced SC 508 to Allendale, and replaced SC 73 to the Georgia state line.^{[citation needed]} When I-95 was built across Lake Marion in 1968,^[8] US 301 and 15 traveled parallel to it until they were relocated in a triple concurrency in 1987.^[9] In 2007, US 301 was rerouted on new 7.51-mile (12.09 km) bypass routing southeast of Florence.^[10]

U.S. Route 217

U.S. Route 217 (US 217) was an original U.S. Highway, established in 1927. A renumbering of SC 23, it traversed from US 17, in Pee Dee, north through Latta and Dillon before entering North Carolina. In 1932, the entire route was renumbered as US 301.

Major intersections

County	Location	mi[1][2][3] [4][5][6][7]	km	Exit	Destinations	Notes
Savannah River		0.000	0.000		US 301 south (SR 73 south) – Sylvania	Continuation into Georgia
					Burtons Ferry Bridge
Allendale	​	5.680	9.141		SC 3 (River Road) – Estill, Barnwell
	Allendale	12.890	20.744		US 278 east / SC 125 north – Hampton, Savannah River Site, Augusta	Southern end of US 278 concurrency; southern terminus of SC 125
		13.200	21.243		US 278 west (Barnwell Road) – Barnwell	Northern end of US 278 concurrency
	​	14.340	23.078		SC 641 east (Confederate Highway) – Walterboro	Western terminus of SC 641
	Ulmer	21.420	34.472		SC 300 north – Barnwell	Southern terminus of SC 300
		21.960	35.341		US 321 south – Fairfax, Savannah	Southern end of US 321 concurrency
Salkehatchie River					Bufords Bridge
Bamberg	​	23.860	38.399		US 321 north (Carolina Highway) – Olar, Denmark, Columbia	Northern end of US 321 concurrency
	​	26.540	42.712		SC 64 east (Lowcountry Highway) – Ehrhardt, Walterboro	Southern end of SC 64 concurrency
	​	26.800	43.130		SC 64 west (Lowcountry Highway) – Olar	Northern end of SC 64 concurrency; to Cathedral Bay Heritage Preserve
	Bamberg	38.740	62.346		US 601 south (Broxton Bridge Road) – Hampton	Southern end of US 601 concurrency
		39.620	63.762		US 78 – Denmark, Branchville
South Edisto River					Bridge
Orangeburg	​	45.280	72.871		SC 332 west (Slab Landing Road) – Cope, Norway	Eastern terminus of SC 332
	​	52.060	83.782		SC 70 west (Binnicker Bridge Road) – Denmark, Barnwell	Eastern terminus of SC 70
	Edisto	55.140	88.739		SC 4 west (Neeses Road) – Neeses	Southern end of SC 4 concurrency
	Orangeburg	56.990	91.717		SC 33 north (Russell Street)	Southern terminus of SC 33
		57.160	91.990		US 601 Truck north / SC 4 east (Stonewall Jackson Street) / Riverside Drive north – Orangeburg National Fish Hatchery, Airport, Orangeburg Arts Center	Northern end of SC 4 concurrency; southern terminus of US 601 Truck
		57.610	92.714		US 178 Bus. (Broughton Street) – North, Bowman
		58.170	93.616		US 601 north / US 21 Bus. (Magnolia Street) – Charleston, St. Matthews, Columbia	Northern end of US 601 concurrency; to Fairgrounds
		59.600	95.917		US 21 / US 178 / US 601 Truck (Joe S. Jeffords Highway) – Charleston, North, Columbia
	​	65.910	106.072		I-26 – Charleston, Columbia	I-26 exits 154 A-B
	​	72.040	115.937		US 176 (Old State Road) – Holly Hill, Cameron
	​	72.560	116.774		SC 47 east (Cleveland Street) – Elloree	Western terminus of SC 47; to Santee State Park
	​	78.020	125.561		SC 267 (Tee Vee Road) – Holly Hill, Elloree
	​	79.620	128.136		US 15 south / US 15 Conn. north (Bass Drive) – St. George, Santee, Santee State Park	Southern end of US 15 concurrency; southern terminus of US 15 Conn.; SCHP Patrolman Harry B. Ray Memorial Intersection
	​	80.608– 80.947	129.726– 130.272		I-95 south / Five Chop Road east (SC 6 Conn. east) – Savannah	Southern end of I-95 concurrency; western terminus of SC 6 Conn. and Five Chop Road; I-95 exit 97; northbound exit and southbound entrance
	​	82.632	132.983	98	SC 6 – Eutawville, Santee, Elloree	Exit number follows I-95
Lake Marion		84.442– 84.448	135.896– 135.906	Williams James Gooding Bridge
Clarendon	​	86.273– 86.312	138.843– 138.906		I-95 north – Florence	Northern end of I-95 concurrency; I-95 exit 102; northbound entrance and southbound exit
	Summerton	93.712	150.815		US 15 north (Church Street) – Sumter	Northern end of US 15 concurrency
		93.777	150.919		Railroad Avenue west (US 15 Conn. north)	Southern terminus of US 15 Conn.; eastern terminus of Railroad Avenue
	​	99.162	159.586		I-95 – Savannah, Florence	I-95 exit 115
	Manning	103.872	167.166		SC 260 (Mill Street) – Jordan	To Santee Dam
		104.222	167.729		SC 261 (Boyce Street) to US 521 – Kingstree, Georgetown, Columbia
		104.962	168.920		US 521 south (Church Street) – Georgetown	Southern end of US 521 concurrency
	​	106.282	171.044		US 521 north – Sumter	Northern end of US 521 concurrency
	​	107.822	173.523		Trinity Church Road west (US 301 Conn. north) – Alcolu	Southern terminus of US 301 Conn.; eastern terminus of Trinity Church Road
	Sardinia	116.382	187.299		SC 527 (Black River Road) – Kingstree, Sumter
	Turbeville	122.302	196.826		US 378 west (Clarence Coker Highway) – Sumter	Southern end of US 378 concurrency
		122.402	196.987		SC 58 north (Gamble Street) – Lynchburg, Bishopville	Southern terminus of SC 58
		123.022	197.985		US 378 east – Lake City, Conway, Myrtle Beach	Northern end of US 378 concurrency
Florence	Olanta	128.752	207.206		SC 341 (Hampton Street) – Lake City, Lynchburg, Timmonsville, Bishopville	To Woods Bay State Natural Area
	Kelley Crossroads	132.122	212.630		SC 403 (Bethel Road) – Lake City
	Effingham	142.772	229.769		US 52 south / SC 327 north – Lake City	Southern end of US 52 concurrency; southern terminus of SC 327
	Florence	148.622	239.184		US 52 north / US 52 Truck begins – Florence	Northern end of US 52 concurrency; southern end of US 52 Truck concurrency; southern terminus of US 52 Truck
		149.892	241.228		US 52 Truck north (South Church Street) to US 52 – Darlington	Northern end of US 52 Truck concurrency
		150.162	241.662		SC 51 (Pamplico Highway) – Pamplico
	​	156.112	251.238		US 76 west (Marion Highway) / SC 327 north (Williston Road) to I-20 / I-95 – Florence	Southern end of US 76/SC 327 concurrency
	Mars Bluff	157.802	253.958		SC 327 south (Francis Marion Road) – Pamplico	Southern end of SC 327 concurrency
Great Pee Dee River					David Walker Harwell Bridge
Marion	Pee Dee	164.942	265.448		US 76 east – Marion, Myrtle Beach	Partial interchange; northern end of US 76 concurrency
Dillon	​	173.102– 173.122	278.581– 278.613		SC 38 – Marion, Bennettsville	Interchange
	Latta	175.425	282.319		US 501 south – Marion, Myrtle Beach	Southern end of US 501 concurrency
		176.184	283.541		SC 917 (Main Street) – Mullins, Bennettsville
	Dillon	182.764	294.130		SC 9 south / SC 34 west / SC 57 south (Main Street) – Lake View, North Myrtle Beach	Southern end of SC 9/SC 57 concurrency; eastern terminus of SC 34
		183.704	295.643		SC 9 north / SC 57 north (Radford Boulevard) – Bennettsville, Charlotte	Northern end of SC 9/SC 57 concurrency
South Carolina–North Carolina line		189.704	305.299		I-95 – Florence, Fayetteville, Lumberton	I-95 exit 1
					US 301 north / US 501 north	Continuation into North Carolina
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus