UBE2J1
Identifiers
Aliases	UBE2J1, HSPC153, HSPC205, HSU93243, NCUBE-1, NCUBE1, UBC6, Ubc6p, CGI-76, UBC6E, ubiquitin conjugating enzyme E2 J1
External IDs	OMIM: 616175 MGI: 1926245 HomoloGene: 41090 GeneCards: UBE2J1
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q15 Start 89,326,625 bp[1] End 89,352,722 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 A5 Start 33,031,416 bp[2] End 33,052,363 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm monocyte bone marrow cells parotid gland rectum amniotic fluid thymus appendix lymph node islet of Langerhans Top expressed in seminiferous tubule lacrimal gland ectoderm otic placode saccule facial motor nucleus anterior horn of spinal cord spermatid medial vestibular nucleus retinal pigment epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding ATP binding ubiquitin protein ligase binding ubiquitin protein ligase activity ubiquitin conjugating enzyme activity Cellular component cytoplasm membrane integral component of membrane endoplasmic reticulum membrane endoplasmic reticulum Biological process protein N-linked glycosylation via asparagine protein ubiquitination ubiquitin-dependent ERAD pathway spermatid development negative regulation of retrograde protein transport, ER to cytosol Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51465 56228 Ensembl ENSG00000198833 ENSMUSG00000028277 UniProt Q9Y385 Q9JJZ4 RefSeq (mRNA) NM_016021 NM_019586 NM_001355494 RefSeq (protein) NP_057105 NP_062532 NP_001342423 Location (UCSC) Chr 6: 89.33 – 89.35 Mb Chr 4: 33.03 – 33.05 Mb PubMed search [3] [4]
Wikidata
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Ubiquitin-conjugating enzyme E2 J1 is a protein that in humans is encoded by the UBE2J1 gene.^[5][6]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s.

This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum (ER) and may contribute to quality control ER-associated degradation by the ubiquitin-proteasome system.^[6]