UBE2L6

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1WZV, 1WZW, 2KJH

Identifiers

Aliases

UBE2L6, RIG-B, UBCH8, ubiquitin conjugating enzyme E2 L6

External IDs

OMIM: 603890 MGI: 1914500 HomoloGene: 3112 GeneCards: UBE2L6

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11q12.1	Start	57,551,656 bp^[1]
Band	11q12.1	End	57,568,284 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2\|2 D	Start	84,629,172 bp^[2]
Band	2\|2 D	End	84,640,679 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

monocyte

palpebral conjunctiva

ganglionic eminence

lymph node

spleen

appendix

gallbladder

stromal cell of endometrium

blood

right lung

Top expressed in

blood

yolk sac

spleen

blastocyst

duodenum

jejunum

aortic valve

ascending aorta

morula

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	ubiquitin-like protein transferase activity transferase activity ISG15 transferase activity protein binding ubiquitin-protein transferase activity ubiquitin binding ubiquitin protein ligase binding ubiquitin conjugating enzyme activity
Cellular component	cytosol nucleoplasm ubiquitin ligase complex
Biological process	ISG15-protein conjugation translesion synthesis negative regulation of type I interferon production modification-dependent protein catabolic process protein ubiquitination ubiquitin-dependent protein catabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9246


56791

Ensembl


ENSG00000156587


ENSMUSG00000027078

UniProt


O14933


Q9QZU9

RefSeq (mRNA)


NM_198183 NM_004223


NM_019949

RefSeq (protein)


NP_004214 NP_937826


NP_064333

Location (UCSC)

Chr 11: 57.55 – 57.57 Mb

Chr 2: 84.63 – 84.64 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Ubiquitin/ISG15-conjugating enzyme E2 L6 is a protein that in humans is encoded by the UBE2L6 gene.^[5]^[6]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1S), ubiquitin-conjugating enzymes (E2S) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family.

This enzyme is highly similar in primary structure to the enzyme encoded by UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.^[6]

Kang HY, Yeh S, Fujimoto N, Chang C (1999). "Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor". J. Biol. Chem. 274 (13): 8570–6. doi:10.1074/jbc.274.13.8570. PMID 10085091.
Moynihan TP, Ardley HC, Nuber U, et al. (1999). "The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1". J. Biol. Chem. 274 (43): 30963–8. doi:10.1074/jbc.274.43.30963. PMID 10521492.
Huang L, Kinnucan E, Wang G, et al. (1999). "Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade". Science. 286 (5443): 1321–6. doi:10.1126/science.286.5443.1321. PMID 10558980.
Nyman TA, Matikainen S, Sareneva T, et al. (2000). "Proteome analysis reveals ubiquitin-conjugating enzymes to be a new family of interferon-alpha-regulated genes". Eur. J. Biochem. 267 (13): 4011–9. doi:10.1046/j.1432-1327.2000.01433.x. PMID 10866800.
Ardley HC, Rose SA, Tan N, et al. (2000). "Genomic organization of the human ubiquitin-conjugating enzyme gene, UBE2L6 on chromosome 11q12". Cytogenet. Cell Genet. 89 (1–2): 137–40. doi:10.1159/000015593. PMID 10894956. S2CID 502452.
Zhang Y, Gao J, Chung KK, et al. (2001). "Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1". Proc. Natl. Acad. Sci. U.S.A. 97 (24): 13354–9. doi:10.1073/pnas.240347797. PMC 27228. PMID 11078524.
Niwa J, Ishigaki S, Doyu M, et al. (2001). "A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity". Biochem. Biophys. Res. Commun. 281 (3): 706–13. doi:10.1006/bbrc.2001.4414. PMID 11237715.
Wheeler TC, Chin LS, Li Y, et al. (2002). "Regulation of synaptophysin degradation by mammalian homologues of seven in absentia". J. Biol. Chem. 277 (12): 10273–82. doi:10.1074/jbc.M107857200. PMID 11786535.
Urano T, Saito T, Tsukui T, et al. (2002). "Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth". Nature. 417 (6891): 871–5. Bibcode:2002Natur.417..871U. doi:10.1038/nature00826. PMID 12075357. S2CID 4348545.
Chin LS, Vavalle JP, Li L (2002). "Staring, a novel E3 ubiquitin-protein ligase that targets syntaxin 1 for degradation". J. Biol. Chem. 277 (38): 35071–9. doi:10.1074/jbc.M203300200. PMID 12121982.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Chuang TH, Ulevitch RJ (2004). "Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors". Nat. Immunol. 5 (5): 495–502. doi:10.1038/ni1066. PMID 15107846. S2CID 39773935.
Zhao C, Beaudenon SL, Kelley ML, et al. (2004). "The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein". Proc. Natl. Acad. Sci. U.S.A. 101 (20): 7578–82. Bibcode:2004PNAS..101.7578Z. doi:10.1073/pnas.0402528101. PMC 419648. PMID 15131269.
Tripathi MK, Chaudhuri G (2005). "Down-regulation of UCRP and UBE2L6 in BRCA2 knocked-down human breast cells". Biochem. Biophys. Res. Commun. 328 (1): 43–8. doi:10.1016/j.bbrc.2004.12.142. PMC 3085986. PMID 15670748.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Li J, Wang J, Yang X, et al. (2007). "The Spen homolog Msx2-interacting nuclear target protein interacts with the E2 ubiquitin-conjugating enzyme UbcH8". Mol. Cell. Biochem. 288 (1–2): 151–7. doi:10.1007/s11010-006-9131-9. PMID 16583136. S2CID 24935755.

v t e PDB gallery
1wzv: Crystal Structure of UbcH8 1wzw: Crystal Structure of UbcH8

Posttranslational modification

Chaperones/
protein folding

Heat shock proteins/ Chaperonins	Hsp10/GroES Hsp27 Hsp47 HSP60/GroEL Hsp40/DnaJ A1 A2 A3 B1 B2 B11 B4 B6 B9 C1 C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α₁ α₂ β ER TRAP1
Other	Alpha crystallin Clusterin Survival of motor neuron SMN1 SMN2

Protein targeting

Ubiquitin
(ubiquitylation)

E1 Ubiquitin-activating enzyme
- UBA1
- UBA2
- UBA3
- UBA5
- UBA6
- UBA7
- ATG7
- NAE1
- SAE1

E2 Ubiquitin-conjugating enzyme
- A
- B
- C
- D1
- D2
- D3
- E1
- E2
- E3
- G1
- G2
- H
- I
- J1
- J2
- K
- L1
- L2
- L3
- L4
- L6
- M
- N
- O
- Q1
- Q2
- R1 (CDC34)
- R2
- S
- V1
- V2
- Z

E3 Ubiquitin ligase
- VHL
- Cullin
- CBL
- MDM2
- FANCL
- UBR1

ATG3
BIRC6
UFC1

Ubiquitin-like proteins
(UBL)

SUMO protein (SUMOylation)	E1 SUMO-activating enzyme SAE1 SAE2 E2 SUMO-conjugating enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4
Other	ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like protein

References

Further reading