UGT2B15

Identifiers

UGT2B15, HLUG4, UDPGT 2B8, UDPGT2B15, UDPGTH3, UGT2B8, UDP glucuronosyltransferase family 2 member B15

External IDs

OMIM: 600069 HomoloGene: 133957 GeneCards: UGT2B15

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	4q13.2	Start	68,646,597 bp^[1]
Band	4q13.2	End	68,670,652 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

gallbladder

liver

right lobe of liver

islet of Langerhans

duodenum

body of pancreas

body of stomach

rectum

fundus

appendix

n/a

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	hexosyltransferase activity glucuronosyltransferase activity glycosyltransferase activity transferase activity retinoic acid binding UDP-glycosyltransferase activity
Cellular component	endoplasmic reticulum membrane membrane intracellular membrane-bounded organelle integral component of membrane organelle membrane endoplasmic reticulum
Biological process	steroid metabolic process cellular glucuronidation metabolism xenobiotic metabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


7366


n/a

Ensembl


ENSG00000277132 ENSG00000196620


n/a

UniProt


P54855


n/a

RefSeq (mRNA)


NM_001076


n/a

RefSeq (protein)


NP_001067


n/a

Location (UCSC)

Chr 4: 68.65 – 68.67 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

UDP-glucuronosyltransferase 2B15 is an enzyme that in humans is encoded by the UGT2B15 gene.^[3]^[4]

The UGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. UGT2B8 demonstrates reactivity with estriol. See UGT2B4 (MIM 600067).[supplied by OMIM]^[4]

References

Coffman BL, Tephly TR, Irshaid YM, et al. (1990). "Characterization and primary sequence of a human hepatic microsomal estriol UDPglucuronosyltransferase". Arch. Biochem. Biophys. 281 (1): 170–5. doi:10.1016/0003-9861(90)90428-2. PMID 2116769.
Irshaid YM, Tephly TR (1987). "Isolation and purification of two human liver UDP-glucuronosyltransferases". Mol. Pharmacol. 31 (1): 27–34. PMID 3100939.
Green MD, Clarke DJ, Oturu EM, et al. (1995). "Cloning and expression of a rat liver phenobarbital-inducible UDP-glucuronosyltransferase (2B12) with specificity for monoterpenoid alcohols". Arch. Biochem. Biophys. 322 (2): 460–8. doi:10.1006/abbi.1995.1489. PMID 7574722.
Green MD, Oturu EM, Tephly TR (1995). "Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates". Drug Metab. Dispos. 22 (5): 799–805. PMID 7835232.
Chen F, Ritter JK, Wang MG, et al. (1993). "Characterization of a cloned human dihydrotestosterone/androstanediol UDP-glucuronosyltransferase and its comparison to other steroid isoforms". Biochemistry. 32 (40): 10648–57. doi:10.1021/bi00091a015. PMID 8399210.
Guillemette C, Lévesque E, Beaulieu M, et al. (1997). "Differential regulation of two uridine diphospho-glucuronosyltransferases, UGT2B15 and UGT2B17, in human prostate LNCaP cells". Endocrinology. 138 (7): 2998–3005. doi:10.1210/endo.138.7.5226. PMID 9202245.
Lévesque E, Beaulieu M, Green MD, et al. (1997). "Isolation and characterization of UGT2B15(Y85): a UDP-glucuronosyltransferase encoded by a polymorphic gene". Pharmacogenetics. 7 (4): 317–25. doi:10.1097/00008571-199708000-00007. PMID 9295060.
Strassburg CP, Strassburg A, Nguyen N, et al. (1999). "Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus". Biochem. J. 338 (2): 489–98. doi:10.1042/0264-6021:3380489. PMC 1220077. PMID 10024527.
Tchernof A, Lévesque E, Beaulieu M, et al. (1999). "Expression of the androgen metabolizing enzyme UGT2B15 in adipose tissue and relative expression measurement using a competitive RT-PCR method". Clin. Endocrinol. 50 (5): 637–42. doi:10.1046/j.1365-2265.1999.00709.x. PMID 10468930. S2CID 43030627.
Strassburg CP, Kneip S, Topp J, et al. (2000). "Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine". J. Biol. Chem. 275 (46): 36164–71. doi:10.1074/jbc.M002180200. PMID 10748067.
Gsur A, Preyer M, Haidinger G, et al. (2002). "A polymorphism in the UDP-Glucuronosyltransferase 2B15 gene (D85Y) is not associated with prostate cancer risk". Cancer Epidemiol. Biomarkers Prev. 11 (5): 497–8. PMID 12010866.
Iida A, Saito S, Sekine A, et al. (2002). "Catalog of 86 single-nucleotide polymorphisms (SNPs) in three uridine diphosphate glycosyltransferase genes: UGT2A1, UGT2B15, and UGT8". J. Hum. Genet. 47 (10): 505–10. doi:10.1007/s100380200075. PMID 12376738.
Court MH, Duan SX, Guillemette C, et al. (2003). "Stereoselective conjugation of oxazepam by human UDP-glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9". Drug Metab. Dispos. 30 (11): 1257–65. doi:10.1124/dmd.30.11.1257. PMID 12386133.
Kanaya J, Takashima M, Koh E, Namiki M (2003). "Androgen-independent growth in LNCaP cell lines and steroid uridine diphosphate-glucuronosyltransferase expression". Asian J. Androl. 5 (1): 9–13. PMID 12646996.
Zhang JY, Zhan J, Cook CS, et al. (2003). "Involvement of human UGT2B7 and 2B15 in rofecoxib metabolism". Drug Metab. Dispos. 31 (5): 652–8. doi:10.1124/dmd.31.5.652. PMID 12695355. S2CID 23434477.
Tomboc M, Witchel SF (2003). "Frequencies of the D85 and Y85 variants of UGT2B15 in children and adolescent girls with hyperandrogenism". J. Pediatr. Endocrinol. Metab. 16 (5): 719–26. doi:10.1515/jpem.2003.16.5.719. PMID 12880121. S2CID 32217321.
Court MH, Hao Q, Krishnaswamy S, et al. (2005). "UDP-glucuronosyltransferase (UGT) 2B15 pharmacogenetics: UGT2B15 D85Y genotype and gender are major determinants of oxazepam glucuronidation by human liver". J. Pharmacol. Exp. Ther. 310 (2): 656–65. doi:10.1124/jpet.104.067660. PMID 15044558. S2CID 5946464.
Toide K, Umeda S, Yamazaki H, et al. (2005). "A major genotype in UDP-glucuronosyltransferase 2B15". Drug Metab. Pharmacokinet. 17 (2): 164–6. doi:10.2133/dmpk.17.164. PMID 15618667.
Chouinard S, Pelletier G, Bélanger A, Barbier O (2005). "Cellular specific expression of the androgen-conjugating enzymes UGT2B15 and UGT2B17 in the human prostate epithelium". Endocr. Res. 30 (4): 717–25. doi:10.1081/ERC-200044014. PMID 15666817. S2CID 10971899.

Transferases: glycosyltransferases (EC 2.4)

2.4.1: Hexosyl-
transferases

Glucosyl-	Phosphorylase Starch Glycogen Cellobiose Myo- Glycogen synthase Debranching enzyme Branching enzyme 1,3-Beta-glucan synthase Ceramide glucosyltransferase N-glycosyltransferase
Galactosyl-	Lactose synthase B-N-acetylglucosaminyl-glycopeptide b-1,4-galactosyltransferase Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase (C1GALT1)
Glucuronosyl-	B3GAT1 B3GAT2 B3GAT3 UGT1A1 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT1A10 UGT2A1 UGT2A2 UGT2A3 UGT2B4 UGT2B7 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 Hyaluronan synthase: HAS1 HAS2 HAS3
Fucosyl-	POFUT1 POFUT2 FUT1 FUT2 FUT3 FUT4 FUT5 FUT6 FUT7 FUT8 FUT9 FUT10 FUT11
Mannosyl-	Dolichyl-phosphate-mannose-protein mannosyltransferase POMT1 POMT2 DPM1 DPM3 ALG1 ALG2 ALG3 ALG6 ALG8 ALG9 ALG12

2.4.2: Pentosyl-
transferases

Ribose

ADP-ribosyltransferase	NAD⁺:diphthamide ADP-ribosyltransferase Diphtheria toxin Pseudomonas exotoxin NAD(P)⁺:arginine ADP-ribosyltransferase Pertussis toxin Cholera toxin Poly ADP ribose polymerase Sirtuin
Phosphoribosyltransferase	Adenine phosphoribosyltransferase Hypoxanthine-guanine phosphoribosyltransferase Uracil phosphoribosyltransferase Amidophosphoribosyltransferase
Other	Purine nucleoside phosphorylase: Thymidine phosphorylase ECGF1

Other

2.4.99: Sialyl
transferases

References

Further reading