Three ships of the United States Navy have been named USS Antietam, after the Battle of Antietam.

• USS Antietam (1864), was a sailing sloop launched in 1864 and used as a stores ship.
• USS Antietam (CV-36), was an aircraft carrier commissioned at the end of World War II, a combatant in the Korean War, and decommissioned in 1963.
• USS Antietam (CG-54), is a guided missile cruiser commissioned in 1987, and currently in active service.