USS Macdonough may refer to the following ships of the United States Navy:

• USS Macdonough (DD-9), was an early destroyer, launched in 1900 and served until 1919
• USS Macdonough (DD-331), was a Clemson-class destroyer, launched in 1920 and served until 1930
• USS Macdonough (DD-351), was a Farragut-class destroyer, launched in 1934 and served through World War II until 1945
• USS Macdonough (DDG-39), was a Farragut-class guided missile frigate (destroyer leader), launched in 1959 and served until 1992