USS Sapphire has been the name of more than one United States Navy ship, and may refer to:

USS Sapphire (SP-710), a patrol vessel in commission from 1917 to 1918
USS Sapphire (PYc-2), a patrol yacht in commission from 1941 to 1945

This article includes a list of ships with the same or similar names. If an internal link for a specific ship led you here, you may wish to change the link to point directly to the intended ship article, if one exists.