SCGB1A1
Identifiers
Aliases	SCGB1A1, CC10, CC16, CCPBP, CCSP, UGB, UP-1, UP1, secretoglobin family 1A member 1
External IDs	OMIM: 192020 MGI: 98919 HomoloGene: 2518 GeneCards: SCGB1A1
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q12.3 Start 62,405,103 bp[1] End 62,423,195 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 9,061,000 bp[2] End 9,065,322 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell right lung urethra lower lobe of lung trachea upper lobe of lung upper lobe of left lung prostate cavity of mouth islet of Langerhans Top expressed in right lung lobe superior surface of tongue left lung left lung lobe trachea esophagus bronchiole skin of abdomen sexually immature organism aorta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function polychlorinated biphenyl binding phospholipase A2 inhibitor activity protein binding Cellular component cytoplasm rough endoplasmic reticulum nuclear envelope intracellular anatomical structure secretory granule extracellular region endoplasmic reticulum extracellular exosome extracellular space Biological process response to cytokine negative regulation of interferon-gamma production negative regulation of interleukin-5 production negative regulation of catalytic activity response to drug negative regulation of interleukin-4 production regulation of mRNA stability female pregnancy response to fibroblast growth factor response to glucocorticoid negative regulation of transcription by RNA polymerase II response to ozone response to organic substance negative regulation of interleukin-13 production response to lipopolysaccharide negative regulation of T cell proliferation regulation of inflammatory response response to silicon dioxide embryo implantation signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7356 22287 Ensembl ENSG00000149021 ENSMUSG00000024653 UniProt P11684 Q06318 RefSeq (mRNA) NM_003357 NM_011681 RefSeq (protein) NP_003348 NP_035811 Location (UCSC) Chr 11: 62.41 – 62.42 Mb Chr 19: 9.06 – 9.07 Mb PubMed search [3] [4]
Wikidata
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Uteroglobin, or blastokinin, also known as secretoglobin family 1A member 1 (SCGB1A1), is a protein that in humans is encoded by the SCGB1A1 gene.^[5]

SCGB1A1 is the founding member of the secretoglobin family of small, secreted, disulfide-bridged dimeric proteins found only in mammals.^[6] This antiparallel disulfide linked homodimeric protein is multifunctional and found in various tissues in various names such as: uteroglobin (UG, UGB), uteroglobin-like antigen (UGL), blastokinin, club-cell secretory protein (CCSP), Clara-cell 16 kD protein (17 in rat/mice), club-cell-specific 10 kD protein (CC10), human protein 1, urine protein 1 (UP-1), polychlorinated biphenyl-binding protein (PCB-BP), human club cell phospholipid-binding protein (hCCPBP), secretoglobin 1A member 1 (SCGB1A1).^[7]

This protein is specifically expressed in club cells in the lungs.^[8]

Function

The precise physiological role of uteroglobin is not yet known. Putative functions are:

1. Immunomodulation
2. Progesterone binding: weak in some animals, especially weak in humans. (Note: UGB is itself progesterone induced gene in the endometrium in Lagomorphs)
3. Inhibits phospholipase A2 in vitro
4. Binds phosphatidylcholine, phosphatidylinositol
5. Binds to fibronectin: The uteroglobulin knockout mice on the inbred C57Bl6 strain develop Goodpasture's syndrome like glomerulopathy due to fibronectin binding of IgA which might potentially be prevented by uteroglobin replacement. However contrary to the animal model claims, human genetic data might suggest that the effect may be indirect^[9]
6. Uteroglobin knockout mice on the inbred 129 strain appear to have healthy phenotype (no glomerulopathy development), but show physiological differences in their responses to respiratory challenges. The phenotype exhibited by these mice are; decreased bioaccumulation of biphenyls, susceptibility and increased IL-13, and IL-6 following hyperoxic challenge, and changes in the club cell morphology. ^[10]
7. Target of polychlorinated biphenyl (pcb) binding