WASL
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesWASL, N-WASP, NWASP, WASPB, WASL (gene), Wiskott-Aldrich syndrome like, WASP like actin nucleation promoting factor
External IDsOMIM: 605056 HomoloGene: 136779 GeneCards: WASL
Orthologs
SpeciesHumanMouse
Entrez

8976

n/a

Ensembl

ENSG00000106299

n/a

UniProt

O00401

n/a

RefSeq (mRNA)

NM_003941

n/a

RefSeq (protein)

NP_003932

n/a

Location (UCSC)Chr 7: 123.68 – 123.75 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Neural Wiskott–Aldrich syndrome protein is a protein that in humans is encoded by the WASL gene.[3][4][5]

The Wiskott–Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. The WASL gene product is a homolog of WAS protein, however, unlike the latter, it is ubiquitously expressed and shows highest expression in neural tissues. It has been shown to bind Cdc42 directly, and induce formation of long actin microspikes.[5]

According to one study, mouse DAB1 regulates actin cytoskeleton through N-WASP.[6]

Diseases associated with WASL include Wiskottt-Aldrich Syndrome and Vaccinia.[7]

Interactions

WASL (gene) has been shown to interact with:

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000106299 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ a b Miki H, Sasaki T, Takai Y, Takenawa T (Jan 1998). "Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP". Nature. 391 (6662): 93–6. Bibcode:1998Natur.391...93M. doi:10.1038/34208. PMID 9422512. S2CID 4363890.
  4. ^ Fukuoka M, Miki H, Takenawa T (Sep 1997). "Identification of N-WASP homologs in human and rat brain". Gene. 196 (1–2): 43–8. doi:10.1016/S0378-1119(97)00184-4. PMID 9322739.
  5. ^ a b "Entrez Gene: WASL Wiskott–Aldrich syndrome-like".
  6. ^ Suetsugu S, Tezuka T, Morimura T, Hattori M, Mikoshiba K, Yamamoto T, Takenawa T (Nov 2004). "Regulation of actin cytoskeleton by mDab1 through N-WASP and ubiquitination of mDab1". The Biochemical Journal. 384 (Pt 1): 1–8. doi:10.1042/BJ20041103. PMC 1134082. PMID 15361067.
  7. ^ "WASL Gene - GeneCards | WASL Protein | WASL Antibody". www.genecards.org. Retrieved 2018-11-25.
  8. ^ Carlier MF, Nioche P, Broutin-L'Hermite I, Boujemaa R, Le Clainche C, Egile C, Garbay C, Ducruix A, Sansonetti P, Pantaloni D (Jul 2000). "GRB2 links signaling to actin assembly by enhancing interaction of neural Wiskott–Aldrich syndrome protein (N-WASp) with actin-related protein (ARP2/3) complex". The Journal of Biological Chemistry. 275 (29): 21946–52. doi:10.1074/jbc.M000687200. PMID 10781580.
  9. ^ Mizutani K, Miki H, He H, Maruta H, Takenawa T (Feb 2002). "Essential role of neural Wiskott–Aldrich syndrome protein in podosome formation and degradation of extracellular matrix in src-transformed fibroblasts". Cancer Research. 62 (3): 669–74. PMID 11830518.
  10. ^ Rohatgi R, Nollau P, Ho HY, Kirschner MW, Mayer BJ (Jul 2001). "Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway". The Journal of Biological Chemistry. 276 (28): 26448–52. doi:10.1074/jbc.M103856200. PMID 11340081.
  11. ^ Mimuro H, Suzuki T, Suetsugu S, Miki H, Takenawa T, Sasakawa C (Sep 2000). "Profilin is required for sustaining efficient intra- and intercellular spreading of Shigella flexneri". The Journal of Biological Chemistry. 275 (37): 28893–901. doi:10.1074/jbc.M003882200. PMID 10867004.
  12. ^ Suetsugu S, Miki H, Takenawa T (Nov 1998). "The essential role of profilin in the assembly of actin for microspike formation". The EMBO Journal. 17 (22): 6516–26. doi:10.1093/emboj/17.22.6516. PMC 1170999. PMID 9822597.
  13. ^ Abe T, Kato M, Miki H, Takenawa T, Endo T (Jan 2003). "Small GTPase Tc10 and its homologue RhoT induce N-WASP-mediated long process formation and neurite outgrowth". Journal of Cell Science. 116 (Pt 1): 155–68. doi:10.1242/jcs.00208. PMID 12456725.

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