WIPI2
Identifiers
Aliases	WIPI2, ATG18B, Atg21, WIPI-2, CGI-50, WD repeat domain, phosphoinositide interacting 2, IDDSSA
External IDs	OMIM: 609225 MGI: 1923831 HomoloGene: 90887 GeneCards: WIPI2
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p22.1 Start 5,190,196 bp[1] End 5,233,840 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G2 Start 142,613,453 bp[2] End 142,656,343 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus Brodmann area 23 nipple olfactory bulb inferior ganglion of vagus nerve ventral tegmental area parotid gland pons endothelial cell amniotic fluid Top expressed in spermatocyte lacrimal gland dorsomedial hypothalamic nucleus morula superior frontal gyrus spermatid seminiferous tubule ventral tegmental area lip medial dorsal nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatidylinositol-5-phosphate binding protein binding phosphatidylinositol-3-phosphate binding phosphatidylinositol-3,5-bisphosphate binding lipid binding Cellular component autophagosome cytosol phagophore assembly site membrane membrane phagophore assembly site extrinsic component of membrane nucleoplasm protein-containing complex Biological process autophagy autophagosome maturation macroautophagy autophagosome assembly autophagy of mitochondrion protein lipidation autophagy of nucleus protein localization to phagophore assembly site protein lipidation involved in autophagosome assembly xenophagy cellular response to starvation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26100 74781 Ensembl ENSG00000157954 ENSMUSG00000029578 UniProt Q9Y4P8 Q80W47 RefSeq (mRNA) NM_001033518 NM_001033519 NM_001033520 NM_001278299 NM_015610 NM_016003 NM_178398 RefSeq (protein) NP_001028690 NP_001028691 NP_001028692 NP_001265228 NP_056425 NP_057087 NP_056425.1 NP_848485 Location (UCSC) Chr 7: 5.19 – 5.23 Mb Chr 5: 142.61 – 142.66 Mb PubMed search [3] [4]
Wikidata
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WD repeat domain phosphoinositide-interacting protein 2 is a protein that in humans is encoded by the WIPI2 gene.^[5][6]

Function

WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids.^[5][6]

WIPI2 is the mammalian homolog of Atg18, not Atg21, along with the closely related protein, WIPI1. WIPI2 mRNA is readily detectable in several commonly used laboratory cell lines (HEK293A, HeLa, A431) and several cancer cell lines, while WIPI1 expression is limited to cancer cells ^{[citation needed]} (but is also detected in many human tissues).

The Atg proteins regulate autophagy, which is a lysosomal degradation pathway required for maintaining cell health, surviving periods of nutrient deprivation and also plays a role in cancer, neurodegeneration and immune responses to a diverse range of pathogens.^[7] WIPI2 is recruited early to the forming autophagosome, along with DFCP-1, ULK-1 and Atg16, where it positively regulates the lipidation of Atg8 (LC3). This is not true for WIPI1.