WNT10A
Identifiers
AliasesWNT10A, OODD, SSPS, STHAG4, Wnt family member 10A
External IDsOMIM: 606268 MGI: 108071 HomoloGene: 22525 GeneCards: WNT10A
Orthologs
SpeciesHumanMouse
Entrez

80326

22409

Ensembl

ENSG00000135925

ENSMUSG00000026167

UniProt

Q9GZT5

P70701

RefSeq (mRNA)

NM_025216

NM_009518

RefSeq (protein)

NP_079492

NP_033544

Location (UCSC)Chr 2: 218.88 – 218.9 MbChr 1: 74.83 – 74.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Wnt-10a is a protein that in humans is encoded by the WNT10A gene.[5][6][7]

Function

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family.[5]

Clinical significance

WNT10A is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region.[5]

Mutations in the WNT10A gene are associated with Schöpf–Schulz–Passarge syndrome[8] and hypodontia.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135925 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026167 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c "Entrez Gene: wingless-type MMTV integration site family".
  6. ^ Kirikoshi H, Sekihara H, Katoh M (May 2001). "WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly coexpressed in SW480 cells". Biochem. Biophys. Res. Commun. 283 (4): 798–805. doi:10.1006/bbrc.2001.4855. PMID 11350055.
  7. ^ Adaimy L, Chouery E, Megarbane H, Mroueh S, Delague V, Nicolas E, Belguith H, de Mazancourt P, Megarbane A (October 2007). "Mutation in WNT10A is associated with an autosomal recessive ectodermal dysplasia: the odonto-onycho-dermal dysplasia". Am. J. Hum. Genet. 81 (4): 821–8. doi:10.1086/520064. PMC 1973944. PMID 17847007.
  8. ^ Bohring A, Stamm T, Spaich C, Haase C, Spree K, Hehr U, Hoffmann M, Ledig S, Sel S, Wieacker P, Röpke A (July 2009). "WNT10A mutations are a frequent cause of a broad spectrum of ectodermal dysplasias with sex-biased manifestation pattern in heterozygotes". Am. J. Hum. Genet. 85 (1): 97–105. doi:10.1016/j.ajhg.2009.06.001. PMC 2706962. PMID 19559398.
  9. ^ van den Boogaard MJ, Créton M, Bronkhorst Y, van der Hout A, Hennekam E, Lindhout D, Cune M, Ploos van Amstel HK (May 2012). "Mutations in WNT10A are present in more than half of isolated hypodontia cases" (PDF). J. Med. Genet. 49 (5): 327–31. doi:10.1136/jmedgenet-2012-100750. PMID 22581971. S2CID 8815004.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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