WNT11
Identifiers
AliasesWNT11, HWnt family member 11
External IDsOMIM: 603699 MGI: 101948 HomoloGene: 20970 GeneCards: WNT11
Orthologs
SpeciesHumanMouse
Entrez

7481

22411

Ensembl

ENSG00000085741

ENSMUSG00000015957

UniProt

O96014

P48615

RefSeq (mRNA)

NM_004626

NM_001285792
NM_001285794
NM_001285795
NM_009519

RefSeq (protein)

NP_004617

NP_001272721
NP_001272723
NP_001272724
NP_033545

Location (UCSC)Chr 11: 76.19 – 76.21 MbChr 7: 98.48 – 98.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein Wnt-11 is a protein that in humans is encoded by the WNT11 gene.[5][6]

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 97%, 85%, and 63% amino acid identity with mouse, chicken, and Xenopus Wnt11 protein, respectively. This gene plays roles in the development of bones, kidneys,[7] and lungs,[8] and is associated with early onset osteoporosis. [9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000085741 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015957 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lako M, Strachan T, Bullen P, Wilson DI, Robson SC, Lindsay S (Dec 1998). "Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung". Gene. 219 (1–2): 101–10. doi:10.1016/S0378-1119(98)00393-X. PMID 9757009.
  6. ^ "Entrez Gene: WNT11 wingless-type MMTV integration site family, member 11".
  7. ^ Majumdar A, Vainio S, Kispert A, McMahon J, McMahon AP (2003-07-15). "Wnt11andRet/Gdnfpathways cooperate in regulating ureteric branching during metanephric kidney development". Development. The Company of Biologists. 130 (14): 3175–3185. doi:10.1242/dev.00520. ISSN 1477-9129. PMID 12783789. S2CID 25866889.
  8. ^ Lako M, Strachan T, Bullen P, Wilson D, Robson S, Lindsay S (1998). "Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung". Gene. Elsevier BV. 219 (1–2): 101–110. doi:10.1016/s0378-1119(98)00393-x. ISSN 0378-1119. PMID 9757009.
  9. ^ Caetano da Silva C, Edouard T, Fradin M, Aubert-Mucca M, Ricquebourg M, Raman R, Salles JP, Charon V, Guggenbuhl P, Muller M, Cohen-Solal M, Collet C (2021-12-07). "WNT11, a new gene associated with early onset osteoporosis, is required for osteoblastogenesis". Human Molecular Genetics. Oxford University Press (OUP). 31 (10): 1622–1634. doi:10.1093/hmg/ddab349. ISSN 0964-6906. PMC 9122655. PMID 34875064.

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