WNT7A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UZQ
Identifiers
Aliases	WNT7A, Wnt family member 7A, Wnt-7a
External IDs	OMIM: 601570 MGI: 98961 HomoloGene: 20969 GeneCards: WNT7A
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p25.1 Start 13,816,258 bp[1] End 13,880,071 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 D1|6 40.45 cM Start 91,340,963 bp[2] End 91,388,345 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence prefrontal cortex cingulate gyrus amygdala right lung Brodmann area 9 gallbladder nucleus accumbens caudate nucleus placenta Top expressed in surface ectoderm corneal epithelium corneal endothelium medial ganglionic eminence cerebellar cortex molar pretectal area main bronchus olfactory bulb utricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function receptor ligand activity cytokine activity frizzled binding protein binding signaling receptor binding Cellular component endocytic vesicle membrane endoplasmic reticulum lumen plasma membrane extracellular fluid extracellular region cell surface Golgi lumen extracellular exosome presynapse synapse Biological process positive regulation of synapse assembly cellular response to transforming growth factor beta stimulus excitatory synapse assembly roof of mouth development non-canonical Wnt signaling pathway cell fate commitment response to estradiol positive regulation of epithelial cell proliferation involved in wound healing chondrocyte differentiation axonogenesis somatic stem cell population maintenance uterus morphogenesis stem cell development positive regulation of canonical Wnt signaling pathway negative regulation of neurogenesis synapse organization somatic stem cell division embryonic digit morphogenesis positive regulation of protein localization to synapse embryonic axis specification sex differentiation negative regulation of apoptotic process positive regulation of JNK cascade wound healing Wnt signaling pathway involved in wound healing, spreading of epidermal cells response to estrogen limb development positive regulation of endothelial cell migration positive regulation of transcription, DNA-templated multicellular organism development regulation of axonogenesis dendritic spine morphogenesis synaptic vesicle recycling uterus development regulation of axon diameter skeletal muscle satellite cell activation positive regulation of gene expression cartilage development regulation of cell population proliferation embryonic limb morphogenesis skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration angiogenesis oviduct development establishment of cell polarity central nervous system vasculogenesis positive regulation of excitatory postsynaptic potential positive regulation of cell population proliferation canonical Wnt signaling pathway synapse assembly positive regulation of excitatory synapse assembly dorsal/ventral pattern formation cell proliferation in forebrain embryonic forelimb morphogenesis neurotransmitter secretion cartilage condensation lens fiber cell development cerebellar granule cell differentiation positive regulation of transcription by RNA polymerase II embryonic hindlimb morphogenesis Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7476 22421 Ensembl ENSG00000154764 ENSMUSG00000030093 UniProt O00755 P24383 RefSeq (mRNA) NM_004625 NM_009527 NM_001363757 RefSeq (protein) NP_004616 NP_033553 NP_001350686 Location (UCSC) Chr 3: 13.82 – 13.88 Mb Chr 6: 91.34 – 91.39 Mb PubMed search [3] [4]
Wikidata
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Protein Wnt-7a is a protein that in humans is encoded by the WNT7A gene.^[5][6][7]

Function

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 99% amino acid identity to the mouse Wnt7A protein. This gene not only guides the development of the anterior-posterior axis in the female reproductive tract but also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. It is also responsive to changes in the levels of sex steroid hormone in the female reproductive tract. Decreased expression of this gene in human uterine leiomyoma is found to be inversely associated with the expression of estrogen receptor alpha.^[7]