Wake Forest may refer to:

• Wake Forest, North Carolina, a town near Raleigh, North Carolina
• Wake Forest University, a university founded in the above town and now located in Winston-Salem, North Carolina
  • Wake Forest School of Medicine, the university's medical school
  • Wake Forest Baptist Medical Center, a hospital affiliated with the university
• Wake Forest, name of the plantation owned by Calvin Jones (physician) that became the first home of Wake Forest University
• Wake Forest Demon Deacons, athletic teams from Wake Forest University