WEE1
PBB Protein WEE1 image.jpg
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesWEE1, WEE1A, WEE1hu, WEE1 G2 checkpoint kinase
External IDsOMIM: 193525 MGI: 103075 HomoloGene: 31152 GeneCards: WEE1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001143976
NM_003390

NM_009516
NM_001355058

RefSeq (protein)

NP_001137448
NP_003381

NP_033542
NP_001341987

Location (UCSC)Chr 11: 9.57 – 9.59 MbChr 7: 109.72 – 109.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

WEE1 homolog (S. pombe), also known as WEE1, is a protein which in humans is encoded by the WEE1 gene.[5]

Function

This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase.[6]

Interactions

Wee1-like protein kinase has been shown to interact with YWHAB[7] and PIN1.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166483 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031016 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Igarashi M, Nagata A, Jinno S, Suto K, Okayama H (September 1991). "Wee1(+)-like gene in human cells". Nature. 353 (6339): 80–3. Bibcode:1991Natur.353...80I. doi:10.1038/353080a0. PMID 1840647. S2CID 2920330.
  6. ^ "Entrez Gene: WEE1 WEE1 homolog (S. pombe)".
  7. ^ Wang, Y; Jacobs C; Hook K E; Duan H; Booher R N; Sun Y (April 2000). "Binding of 14-3-3beta to the carboxyl terminus of Wee1 increases Wee1 stability, kinase activity, and G2-M cell population". Cell Growth Differ. UNITED STATES. 11 (4): 211–9. ISSN 1044-9523. PMID 10775038.
  8. ^ Shen, M; Stukenberg P T; Kirschner M W; Lu K P (March 1998). "The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins". Genes Dev. UNITED STATES. 12 (5): 706–20. doi:10.1101/gad.12.5.706. ISSN 0890-9369. PMC 316589. PMID 9499405.

Further reading