WEE1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X8B, 2IN6, 2IO6, 2Z2W, 3BI6, 3BIZ, 3CQE, 3CR0
Identifiers
Aliases	WEE1, WEE1A, WEE1hu, WEE1 G2 checkpoint kinase
External IDs	OMIM: 193525 MGI: 103075 HomoloGene: 31152 GeneCards: WEE1
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 9,573,670 bp[1] End 9,593,457 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E3 Start 109,721,253 bp[2] End 109,742,493 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastric mucosa embryo ganglionic eminence bronchial epithelial cell skin of abdomen corpus epididymis gallbladder lactiferous duct mucosa of urinary bladder stromal cell of endometrium Top expressed in primitive streak cumulus cell parotid gland endocardial cushion vas deferens pontine nuclei maxillary prominence internal carotid artery foot ureter More reference expression data BioGPS n/a
Gene ontology Molecular function metal ion binding nucleotide binding protein tyrosine kinase activity protein kinase activity transferase activity magnesium ion binding non-membrane spanning protein tyrosine kinase activity ATP binding protein binding kinase activity Cellular component nucleolus nucleoplasm cytoplasm nucleus Biological process cell cycle neuron projection morphogenesis establishment of cell polarity cell division G2/M transition of mitotic cell cycle microtubule cytoskeleton organization peptidyl-tyrosine phosphorylation protein phosphorylation phosphorylation mitotic cell cycle G1/S transition of mitotic cell cycle negative regulation of G1/S transition of mitotic cell cycle mitotic cell cycle checkpoint signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7465 22390 Ensembl ENSG00000166483 ENSMUSG00000031016 UniProt P30291 P47810 RefSeq (mRNA) NM_001143976 NM_003390 NM_009516 NM_001355058 RefSeq (protein) NP_001137448 NP_003381 NP_033542 NP_001341987 Location (UCSC) Chr 11: 9.57 – 9.59 Mb Chr 7: 109.72 – 109.74 Mb PubMed search [3] [4]
Wikidata
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WEE1 homolog (S. pombe), also known as WEE1, is a protein which in humans is encoded by the WEE1 gene.^[5]

Function

This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase.^[6]

Interactions

Wee1-like protein kinase has been shown to interact with YWHAB^[7] and PIN1.^[8]