What Would You Do may refer to:

Film and television

• What Would You Do? (1991 TV program), a 1991–1993 American children's game show
• What Would You Do? (2008 TV program), an American hidden-camera program
• What Would You Do? (film), a 1920 American silent drama film directed by Edmund Lawrence and Denison Clift

Music

• "What Would You Do?" (City High song), 2001
• "What Would You Do?" (Tha Dogg Pound song), 1995
• "What Would You Do (If Jesus Came to Your House)", a song by Porter Wagoner, 1956; covered by Red Sovine the same year
• "What Would You Do?", a song by the Isley Brothers from Body Kiss, 2003
• "What Would You Do?", a song by Jim Reeves from According to My Heart, 1960
• "What Would You Do?", a song by Joel Corry, David Guetta and Bryson Tiller, 2022
• "What Would You Do", a song by Kelly Rowland from Simply Deep, 2002
• "What Would You Do", a song by Mariah Carey, 2003
• "What Would You Do?", a song by Tate McRae from I Used to Think I Could Fly, 2022
• "What Would You Do", a folk song with Roud number 3051