Tourette syndrome

Myth and misinformation is the norm in most published literature about Tourette syndrome; I hope you will find this to be a well-referenced encyclopedic entry that helps clarify some of the common misconceptions about the condition. There is a very old peer review; the article is selected as one of the best at the medicine portal, conforms to the Manual of style for medical articles, has had several independent copy edits, and is extensively cited. The size is a respectable 66KB overall, with 37KB of prose. Self-nom, about 95% written by me, with lots of vandal patrolling by my Wikifriends (please help me watch for the expected coprolalia-related vandalism while it is here at FAC). Thanks in advance for your comments, Sandy (Talk) 20:01, 26 October 2006 (UTC)[reply]

  • In the introduction, why is a number of schoolchildren sufferers only given for America, which gives no information on incidence. The percentage mentioned later in the article would be more widely-applicable.
  • That is the only number (as opposed to prevalance est.) available anywhere in any literature I've seen, and I only found it in new reading this week: if estimates of school children in other countries (other than prevalance, already discussed) are available anywhere, I've never come across them. I wanted something to convey the idea of how "not rare" TS is; that's why I moved that number up. My thinking is that just including the prevalance in the lead wouldn't be "enticing" to the reader, as it wouldn't convey the magnitude of the number. Sandy (Talk) 04:36, 27 October 2006 (UTC)[reply]
Tried a formulation that adds both. Also changed half million to 500,000 as numbers with lots of zeros look larger!
Perfect! Thanks, Sandy (Talk) 13:53, 27 October 2006 (UTC)[reply]
  • You might add an image of the structure of the most-frequently used medication.
  • Nice suggestion, will do. Sandy (Talk) 04:36, 27 October 2006 (UTC)[reply]
  • Some of these refs contain several papers, was this intended?
  • Yes, in cases where multiple (seminal or important) references were used to support one statement, I combined them into one ref tag (something I learned from the Daniel Boone nomination). I think I did that in 4 refs, rather than overburden the text with multiple tags.
  • Refs 70 and 71 are duplicates and could be merged.
  • Ack, thanks! I double-checked the book to make sure I hadn't made a typo, it is the same page, I'll combine. Sandy (Talk) 04:36, 27 October 2006 (UTC)[reply]
  • "Notes" contains the references, so what is the references section for? Is this part of further reading? TimVickers 04:14, 27 October 2006 (UTC)[reply]
  • Notes are specific inline citations; references are a listing of the broader sources used in researching the overall topic - seminal papers quoted often, reviews, and books on the entire topic - per WP:MEDMOS. References are also used for specific inline cites, but as MEDMOS was explained to me, and as I read it, the overall (general) research materials used are listed in References, while inline citations are at Notes. Those are the important Research works; they can't be listed as Further reading, as they are used as a source. Thanks for the help: going to make your changes now. Sandy (Talk) 04:36, 27 October 2006 (UTC)[reply]
Thanks. TimVickers 12:35, 27 October 2006 (UTC)[reply]
  • Thanks so much for all of that, Colin; I'll get on all that after I've had several cups of morning coffee. (The final source used in Research controversies is so seminal and comprehensive it's hard not to use it all -- it covers all current controversies, but I'll see what I can do there.) Sandy (Talk) 13:28, 27 October 2006 (UTC)[reply]
  • Changes made, would appreciate a new set of eyes to have a look now at Research directions and controversies section. The Swerdlow paper is so comprehensive that there isn't much else to say, but I did add info from another source so as not to overly rely on one source. Thanks, Sandy (Talk) 18:13, 27 October 2006 (UTC)[reply]
  • Question Haloperidol image in the Management section: question raised above as to its usefulness. Opinions? Sandy (Talk) 13:53, 27 October 2006 (UTC)[reply]
I, for one, think it's relevant (the Arthur K. Shapiro article does state "a turning point in understanding of Tourette syndrome came...when Dr. Shapiro and his wife... treated a Tourette’s patient with haloperidol"), but as a "pharm guy" as Sandy put it I'm biased :) – Colin's concern (correct me if I'm wrong) may refer to the fact that lay readers may not associate a space-filling model of Haldol with Haldol (or may not recognize what it is). Perhaps linking to "space-filling model" or "molecular model" in the caption? Fvasconcellos 14:05, 27 October 2006 (UTC)[reply]
Pros and cons: I'm not happy having Haldol in there, since it really is a heavy-duty med, with major side effects, is used as a last resort in severe cases, and I don't want the article to appear to "encourage" its use. On the other hand, you are right that it was a turning point in the history. Maybe you can fix the caption? Another option I found, which I like better, is at Adderall: it's a very nice image, and it is important to convey that stimulants are underused in the treatment of TS because of old myths. But, I'm not sure about the licensing tag on that image? Anyone? Sandy (Talk) 14:11, 27 October 2006 (UTC)[reply]
As an image that is very similar to the one that is already used (generic medicine bottle and capsules). I think the Haloperidol image could stay but needs recaptioning. "Haloperidol is used to treat severe cases of Tourette's" tells us neither whether Haloperidol alone is used in this case nor whether it is the only treatment for severe TS. Perhaps even explaining that this is a representation of the molecule might help. Yomanganitalk 14:25, 27 October 2006 (UTC)[reply]
(dedenting)I'd be happy to amend the caption. As for the Adderall pic, I see no major problem with its copyright status. If you look closely, you can see personal details on the prescription bottle have been blanked with White-Out – an indication it is indeed someone's prescription, rather than a commercial image (is this much of a stretch on my part?) Either way, I'll wait for more opinions to emerge, or Sandy's choice. Fvasconcellos 14:29, 27 October 2006 (UTC)[reply]
[edit conflict] Yes, because pharmacological treatment is really an issue for the minority, I had left all of that detail in the daughter article, Treatment of Tourette syndrome; now the need for an image may cause med details to come back to this article. Maybe Fvasconcellos can explain better what that image represents - then I can adjust the wording, and later add the adderall image to the Treatment daughter article. (The images in this article have proven to be a bigger problem than the text :-) Sandy (Talk) 14:32, 27 October 2006 (UTC)[reply]
How about this? Fvasconcellos 14:51, 27 October 2006 (UTC)[reply]
Space-filling representation of a haloperidol molecule. Haloperidol is an antipsychotic medication sometimes used to treat severe cases of Tourette's.
Perfect, if Yomangani agrees that addresses the textual questions about its use, which I hope not to expand on in this article, rather the Treatment article. Thanks again, Fvasconcellos. Sandy (Talk) 14:54, 27 October 2006 (UTC)[reply]
Looks fine to me, now. Yomanganitalk 15:13, 27 October 2006 (UTC)[reply]
Great, thanks, will ask FV to add. Sandy (Talk) 15:16, 27 October 2006 (UTC)[reply]
Done. Sandy (Talk) 15:32, 27 October 2006 (UTC)[reply]
Sorry to have caused so much of an issue with the multi-coloured sex-toy / space-filling jobbie. Yes, I think most lay people reading this article won't appreciate the subtleties that such a model no doubt informs the pharmacologically minded around here. Given the overall impression regarding medication, I think the one photo of the pills is quite enough for this section. Colin°Talk 22:34, 27 October 2006 (UTC)[reply]