William Grace may refer to:

• William Russell Grace (1832–1904), mayor of New York and the founder of W. R. Grace and Company
• W. G. Grace (William Gilbert Grace, 1848–1915), English cricketer
• William M. Grace (1934–2004), casino developer
• Billy Grace (1876–1938), Australian rules footballer
• Willie Grace (1917–2006), American baseball player
• Several of the Grace baronets