chemokine (C motif) ligand 2
Identifiers
SymbolXCL2
Alt. symbolsSCYC2, SCM-1b
NCBI gene6846
HGNC10646
OMIM604828
RefSeqNM_003175
UniProtQ9UBD3
Other data
LocusChr. 1 q24.2
Search for
StructuresSwiss-model
DomainsInterPro

Chemokine (C motif) ligand 2 (XCL2) is a small cytokine belonging to the XC chemokine family that is highly related to another chemokine called XCL1.[1] It is predominantly expressed in activated T cells, but can also be found at low levels in unstimulated cells. XCL2 induces chemotaxis of cells expressing the chemokine receptor XCR1.[2] Its gene is located on chromosome 1 in humans.[3]

References

  1. ^ Kennedy J, Kelner G, Kleyensteuber S, Schall T, Weiss M, Yssel H, Schneider P, Cocks B, Bacon K, Zlotnik A (1995). "Molecular cloning and functional characterization of human lymphotactin". J Immunol. 155 (1): 203–9. doi:10.4049/jimmunol.155.1.203. PMID 7602097.
  2. ^ Yoshida T, Imai T, Kakizaki M, Nishimura M, Takagi S, Yoshie O (1998). "Identification of single C motif-1/lymphotactin receptor XCR1". J Biol Chem. 273 (26): 16551–4. doi:10.1074/jbc.273.26.16551. PMID 9632725.
  3. ^ Yoshida T, Imai T, Takagi S, Nishimura M, Ishikawa I, Yaoi T, Yoshie O (1996). "Structure and expression of two highly related genes encoding SCM-1/human lymphotactin". FEBS Lett. 395 (1): 82–8. doi:10.1016/0014-5793(96)01004-6. PMID 8849694.
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