Yglesias is a surname. Notable people with the surname include:

• The Yglesias literary and journalistic family
  • Helen Yglesias (née Bassine) (1915–2008), American novelist, wife of Jose
  • Jose Yglesias (1919–1995), American novelist, husband of Helen
  • Rafael Yglesias (born 1954), American novelist and screenwriter, son of Jose and Helen
  • Matthew Yglesias (born 1981), American journalist, son of Rafael
• Rafael Yglesias Castro (1861–1924), Costa Rican politician