|Aliases||MAP3K20, AZK, MLK7, MLT, MLTK, MRK, mlklak, pk, ZAK, SFMMP, sterile alpha motif and leucine zipper containing kinase AZK, mitogen-activated protein kinase kinase kinase 20, MLTKalpha, MLTKbeta, CNM6|
|External IDs||OMIM: 609479 MGI: 2443258 HomoloGene: 32331 GeneCards: MAP3K20 |
|Location (UCSC)||Chr 2: 173.08 – 173.27 Mb||Chr 2: 72.12 – 72.27 Mb|
Sterile alpha motif and leucine zipper containing kinase AZK, also known as ZAK, is a human gene.
This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
ZAK has been shown to interact with ZNF33A.