ZBTB33
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LT7, 3FKC, 3M4T, 3M8V, 4F6M, 4F6N
Identifiers
Aliases	ZBTB33, ZNF-kaiso, ZNF348, zinc finger and BTB domain containing 33
External IDs	OMIM: 300329 MGI: 1927290 HomoloGene: 4931 GeneCards: ZBTB33
Gene location (Human) Chr. X chromosome (human)[1] Band Xq24 Start 120,250,752 bp[1] End 120,258,398 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A3.3 Start 37,278,670 bp[2] End 37,285,923 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte endothelial cell Brodmann area 23 corpus epididymis bronchial epithelial cell middle temporal gyrus spongy bone palpebral conjunctiva germinal epithelium ganglionic eminence Top expressed in medial ganglionic eminence hair follicle condyle pineal gland trigeminal ganglion parotid gland fossa Region I of hippocampus proper conjunctival fornix Paneth cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methyl-CpG binding sequence-specific DNA binding DNA binding protein binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component plasma membrane nucleolus nucleus nucleoplasm cytoplasm cytosol Biological process intracellular signal transduction negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated Wnt signaling pathway transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10009 56805 Ensembl ENSG00000177485 ENSMUSG00000048047 UniProt Q86T24 Q8BN78 RefSeq (mRNA) NM_006777 NM_001184742 NM_001079513 NM_020256 RefSeq (protein) NP_001171671 NP_006768 NP_001072981 NP_064652 Location (UCSC) Chr X: 120.25 – 120.26 Mb Chr X: 37.28 – 37.29 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Transcriptional regulator Kaiso is a protein that in humans is encoded by the ZBTB33 gene.^[5] This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.^[6]

NAMED by Dr.Juliet Daniel's, the KAISO gene was named after 'calypso' music popular in the Caribbeans, Trinidad & Tobago, e.t.c.

Interactions

ZBTB33 has been shown to interact with HDAC3,^[7] Nuclear receptor co-repressor 1^[7] and CTNND1.^[8]