ZNF217
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HU2, 3UK3, 4F2J, 4IS1
Identifiers
Aliases	ZNF217, ZABC1, zinc finger protein 217
External IDs	OMIM: 602967 MGI: 2685408 HomoloGene: 4757 GeneCards: ZNF217
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.2 Start 53,567,071 bp[1] End 53,609,907 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 H3|2 89.91 cM Start 169,950,563 bp[2] End 169,990,023 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium palpebral conjunctiva monocyte thymus lactiferous duct blood bone marrow spongy bone bone marrow cells cavity of mouth Top expressed in spermatid medullary collecting duct renal corpuscle primitive streak conjunctival fornix bone marrow otolith organ lymph node utricle spermatocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific protein binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component histone deacetylase complex nucleus mitochondrion nuclear speck nucleoplasm Biological process negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated signal transduction multicellular organism development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7764 228913 Ensembl ENSG00000171940 ENSMUSG00000052056 UniProt O75362 Q3U0X6 RefSeq (mRNA) NM_006526 NM_001385034 NM_001033299 NM_001159683 RefSeq (protein) NP_006517 NP_001028471 NP_001153155 Location (UCSC) Chr 20: 53.57 – 53.61 Mb Chr 2: 169.95 – 169.99 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger protein 217, also known as ZNF217, is a protein which in humans is encoded by the ZNF217 gene.^[5][6]

Function

ZNF217 can attenuate apoptotic signals resulting from telomere dysfunction and may promote neoplastic transformation and later stages of malignancy.^[7] Znf217 was shown to be a prognostic biomarker and therapeutic target during breast cancer progression.^[8]