ZNF74
Identifiers
AliasesZNF74, COS52, ZFP520, ZNF520, hZNF7, zinc finger protein 74
External IDsOMIM: 194548 HomoloGene: 88675 GeneCards: ZNF74
Orthologs
SpeciesHumanMouse
Entrez

7625

n/a

Ensembl

ENSG00000185252

n/a

UniProt

Q16587

n/a

RefSeq (mRNA)

NM_001256523
NM_001256524
NM_001256525
NM_003426

n/a

RefSeq (protein)

NP_001243452
NP_001243453
NP_001243454
NP_003417

n/a

Location (UCSC)Chr 22: 20.39 – 20.41 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Zinc finger protein 74 is a protein that in humans is encoded by the ZNF74 gene.[3][4][5] Schizophrenia susceptibility has been associated with a mutation in this protein.[6]

Interactions

ZNF74 has been shown to interact with POLR2A.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000185252 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Aubry M, Marineau C, Zhang FR, Zahed L, Figlewicz D, Delattre O, Thomas G, de Jong PJ, Julien JP, Rouleau GA (August 1992). "Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2)". Genomics. 13 (3): 641–8. doi:10.1016/0888-7543(92)90135-F. PMID 1639391.
  4. ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (December 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
  5. ^ "Entrez Gene: ZNF74 zinc finger protein 74".
  6. ^ Takase, K.; T. Ohtsuki; O. Migita; M. Toru; T. Inada; K. Yamakawa-Kobayashi; T. Arinami (1 December 2001). "Association of ZNF74 gene genotypes with age-at-onset of schizophrenia". Schizophrenia Research. 52 (3): 161–165. doi:10.1016/s0920-9964(00)00191-2. PMID 11705709. S2CID 42865851.
  7. ^ Grondin B, Côté F, Bazinet M, Vincent M, Aubry M (October 1997). "Direct interaction of the KRAB/Cys2-His2 zinc finger protein ZNF74 with a hyperphosphorylated form of the RNA polymerase II largest subunit". J. Biol. Chem. 272 (44): 27877–85. doi:10.1074/jbc.272.44.27877. PMID 9346935.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Transcription factors and intracellular receptors
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