Zacharia Kamberuka (born 28 December 1987) is a retired Botswanan sprinter who specialized in the 400 metres.

In the 400 metres he finished sixth at the 2011 All-Africa Games^[1] and fifth at the 2015 Summer Universiade. He competed at the 2010 Commonwealth Games (semi-final) and the 2010 African Championships (did not finish) without reaching the final.

In the 4 × 400 metres relay he finished fourth at the 2008 African Championships,^[2] fifth at the 2010 Commonwealth Games,^[1] eighth at the 2015 World Relays and was disqualified in the final at the 2015 Summer Universiade. He also competed at the 2007 All-Africa Games (as a heat runner for the eventual gold medallists), the 2010 World Indoor Championships (disqualified) and the 2012 World Indoor Championships without reaching the final.^{[citation needed]}

His personal best time is 45.71 seconds, achieved in April 2010 in Germiston.^[1] He also co-holds a Botswanan indoor record in the 4 × 400 metres relay, achieved at the 2012 World Indoor Championships.^{[citation needed]}