3D model (JSmol)
|Molar mass||552.47 g·mol−1|
|Occupational safety and health (OHS/OSH):|
|Lethal dose or concentration (LD, LC):|
LD50 (median dose)
|11 μg/kg (mice)|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Zetekitoxin AB (ZTX) is a guanidine alkaloid found in the Panamanian golden frog Atelopus zeteki. It is an extremely potent neurotoxin.
ZTX is a guanidine alkaloid. It's structurally related to saxitoxin, but with some differences. ZTX has a guanidine core similar to saxitoxin. It contains an isoxazolidine ring, a sulfonate group and a N-hydroxycarbamate group.
ZTX is an extremely potent sodium channel blocker. It has been shown to block the voltage-gated sodium channels at picomolar concentrations. It is about 580 times more potent than saxitoxin.
ZTX is an extremely potent neurotoxin. The LD50 of ZTX in mice is 11 μg/kg.