Zhou Yi may refer to:
- The I Ching, also known as Zhouyi, one of the oldest of the Chinese classic texts
- Zhou Yi (Jin Dynasty) (269–322), style name Boren, official of the Western and Eastern Jin dynasties
- Zhou Yi (musician), Shanghai born and New York-based Chinese pipa virtuoso
- Zhou Yi (softball) (born 1983), female Chinese softball player who competed at the 2004 Summer Olympics
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