Zofenoprilat
Names
IUPAC name
(4S)-N-[(2S)-2-Methyl-3-sulfanylpropanoyl]-4-(phenylsulfanyl)-L-proline
Systematic IUPAC name
(2S,4S)-1-[(2S)-2-Methyl-3-sulfanylpropanoyl]-4-(phenylsulfanyl)pyrrolidine-2-carboxylic acid
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
DrugBank
UNII
  • InChI=1S/C15H19NO3S2/c1-10(9-20)14(17)16-8-12(7-13(16)15(18)19)21-11-5-3-2-4-6-11/h2-6,10,12-13,20H,7-9H2,1H3,(H,18,19)/t10-,12-,13-/m0/s1
    Key: UQWLOWFDKAFKAP-DRZSPHRISA-N
  • InChI=1/C15H19NO3S2/c1-10(9-20)14(17)16-8-12(7-13(16)15(18)19)21-11-5-3-2-4-6-11/h2-6,10,12-13,20H,7-9H2,1H3,(H,18,19)/t10-,12-,13-/m0/s1
    Key: UQWLOWFDKAFKAP-DRZSPHRIBV
  • C[C@H](CS)C(=O)N1C[C@H](C[C@H]1C(O)=O)SC1=CC=CC=C1
Properties
C15H19NO3S2
Molar mass 325.44 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Zofenoprilat is an angiotensin-converting enzyme inhibitor, and is the free sulfhydryl active metabolite of zofenopril.[1]

References

  1. ^ Subissi, A; Evangelista, S; Giachetti, A (1999). "Preclinical Profile of Zofenopril: An Angiotensin Converting Enzyme Inhibitor with Peculiar Cardioprotective Properties". Cardiovascular Drug Reviews. 17 (2): 115. doi:10.1111/j.1527-3466.1999.tb00008.x.


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