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Lumateperonum
Cognitores
ChemSpider 7997690
PubChem 9821941
DrugBank DB06077
Natura chemica
Lumateperonum
Formula summarum C
24H
28FN
3O
Massa molaris 393.506 g/mol
Ad usum therapeuticum
Applicatio per os
MedlinePlus a620014 (Anglice)

Lumateperonum (antea: ITI-007) est antipsychotica atypicum et medicamentum ad therapiam schizophreniarum praescriptum[1]. Virtutes suae ad systemata et serotonergicum et dopaminergicum et glutamatergicum spectant[2].

Natura Lumateperoni

Natura chemica

Structura chemica Lumateperoni est 1-(4-Fluorophenylo)-4-(3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyridino[3',4':4,5]pyrrolo[1,2,3-de]quinoxalino-8(7H)-yl)-1-butanonum. Massa molaris est 393.506 g/mol.

Pharmacodynamica

Receptorium Lumateperoni affinitas
ligandi, Ki (nM)[3]		 Actio
dopamini D1 4.1
dopamini D2 3.2 prae- et postsynapticum
serotonini 5-HT2A 0.54
SERT 3.3

Lumateperonum receptoria D2 postsynaptica inhibet, at etiam agonista praesynapticarum receptoriorum D2 agit. Praeterea inhibitio receptoriorum serotonergicorum 5HT2A descripta est.

Nexus interni

Notae

  1. ↑ Vyas P., Hwang B. J., Brašić J. R. (Feb 2020). An evaluation of lumateperone tosylate for the treatment of schizophrenia. 21. pp. 139-45 
  2. ↑ Kumar B., Kuhad A., Kuhad A. (Dec 2018). "Lumateperone: a new treatment approach for neuropsychiatric disorders". Drugs of today 54 (12): 713-9 
  3. ↑ https://web.archive.org/web/20131108013656/http://pdsp.med.unc.edu/pdsp.php
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