Formil peptidni receptor 2

Identifikatori

FPR2; FPRL1; ALXR; FMLP-R-II; FMLPX; FPR2A; FPRH1; FPRH2; HM63; LXA4R

Vanjski ID

OMIM: 136538 MGI: 1278319 HomoloGene: 74395 IUPHAR: FPR2/ALX GeneCards: FPR2 Gene

Ontologija gena
Molekularna funkcija	• rodopsinu-slična receptorska aktivnost • receptorska aktivnost • N-formil peptidna receptorska aktivnost
Celularna komponenta	• ćelijska membrana • integralno sa membranom
Biološki proces	• ćelijska motilnost • hemotaksa • inflamatorni respons • ćelijska adhezija • prenos signala • signalni put G-protein spregnutog receptora

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

RefSeq (mRNA)

RefSeq (protein)

Lokacija (UCSC)

Chr 19:
56.96 - 56.97 Mb

Chr 17:
18.02 - 18.03 Mb

PubMed pretraga

[1]

[2]

N-formil peptidni receptor 2 je protein koji je kod ljudi kodiran FPR2 genom.^[1]^[2]

Reference

↑ Maddox JF, Hachicha M, Takano T, Petasis NA, Fokin VV, Serhan CN (Apr 1997). „Lipoxin A4 stable analogs are potent mimetics that stimulate human monocytes and THP-1 cells via a G-protein-linked lipoxin A4 receptor”. J Biol Chem 272 (11): 6972–8. PMID 9054386.
↑ „Entrez Gene: FPRL1 Formyl peptide receptor-like 1”.

Literatura

Murphy PM, Ozçelik T, Kenney RT, et al. (1992). „A structural homologue of the N-formyl peptide receptor. Characterization and chromosome mapping of a peptide chemoattractant receptor family.”. J. Biol. Chem. 267 (11): 7637–43. PMID 1373134.
Ye RD, Cavanagh SL, Quehenberger O, et al. (1992). „Isolation of a cDNA that encodes a novel granulocyte N-formyl peptide receptor.”. Biochem. Biophys. Res. Commun. 184 (2): 582–9. DOI:10.1016/0006-291X(92)90629-Y. PMID 1374236.
Perez HD, Holmes R, Kelly E, et al. (1992). „Cloning of a cDNA encoding a receptor related to the formyl peptide receptor of human neutrophils.”. Gene 118 (2): 303–4. DOI:10.1016/0378-1119(92)90208-7. PMID 1511907.
Bao L, Gerard NP, Eddy RL, et al. (1992). „Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19.”. Genomics 13 (2): 437–40. DOI:10.1016/0888-7543(92)90265-T. PMID 1612600.
Nomura H, Nielsen BW, Matsushima K (1994). „Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors.”. Int. Immunol. 5 (10): 1239–49. DOI:10.1093/intimm/5.10.1239. PMID 7505609.
Durstin M, Gao JL, Tiffany HL, et al. (1994). „Differential expression of members of the N-formylpeptide receptor gene cluster in human phagocytes.”. Biochem. Biophys. Res. Commun. 201 (1): 174–9. DOI:10.1006/bbrc.1994.1685. PMID 8198572.
Takano T, Fiore S, Maddox JF, et al. (1997). „Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors.”. J. Exp. Med. 185 (9): 1693–704. DOI:10.1084/jem.185.9.1693. PMID 9151906.
Gronert K, Gewirtz A, Madara JL, Serhan CN (1998). „Identification of a human enterocyte lipoxin A4 receptor that is regulated by interleukin (IL)-13 and interferon gamma and inhibits tumor necrosis factor alpha-induced IL-8 release.”. J. Exp. Med. 187 (8): 1285–94. DOI:10.1084/jem.187.8.1285. PMID 9547339.
Deng X, Ueda H, Su SB, et al. (1999). „A synthetic peptide derived from human immunodeficiency virus type 1 gp120 downregulates the expression and function of chemokine receptors CCR5 and CXCR4 in monocytes by activating the 7-transmembrane G-protein-coupled receptor FPRL1/LXA4R.”. Blood 94 (4): 1165–73. PMID 10438703.
Chiang N, Fierro IM, Gronert K, Serhan CN (2000). „Activation of lipoxin A(4) receptors by aspirin-triggered lipoxins and select peptides evokes ligand-specific responses in inflammation.”. J. Exp. Med. 191 (7): 1197–208. DOI:10.1084/jem.191.7.1197. PMID 10748237.
Shen W, Proost P, Li B, et al. (2000). „Activation of the chemotactic peptide receptor FPRL1 in monocytes phosphorylates the chemokine receptor CCR5 and attenuates cell responses to selected chemokines.”. Biochem. Biophys. Res. Commun. 272 (1): 276–83. DOI:10.1006/bbrc.2000.2770. PMID 10872839.
Le Y, Jiang S, Hu J, et al. (2000). „N36, a synthetic N-terminal heptad repeat domain of the HIV-1 envelope protein gp41, is an activator of human phagocytes.”. Clin. Immunol. 96 (3): 236–42. DOI:10.1006/clim.2000.4896. PMID 10964542.
De Yang , Chen Q, Schmidt AP, et al. (2000). „LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells.”. J. Exp. Med. 192 (7): 1069–74. DOI:10.1084/jem.192.7.1069. PMID 11015447.
Kang Y, Taddeo B, Varai G, et al. (2000). „Mutations of serine 236-237 and tyrosine 302 residues in the human lipoxin A4 receptor intracellular domains result in sustained signaling.”. Biochemistry 39 (44): 13551–7. DOI:10.1021/bi001196i. PMID 11063592.
Svensson L, Dahlgren C, Wennerås C (2002). „The chemoattractant Trp-Lys-Tyr-Met-Val-D-Met activates eosinophils through the formyl peptide receptor and one of its homologues, formyl peptide receptor-like 1.”. J. Leukoc. Biol. 72 (4): 810–8. PMID 12377951.
He R, Sang H, Ye RD (2003). „Serum amyloid A induces IL-8 secretion through a G protein-coupled receptor, FPRL1/LXA4R.”. Blood 101 (4): 1572–81. DOI:10.1182/blood-2002-05-1431. PMID 12393391.
Christophe T, Karlsson A, Rabiet MJ, et al. (2002). „Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1/LXA4R, is not affected by lipoxin A4.”. Scand. J. Immunol. 56 (5): 470–6. DOI:10.1046/j.1365-3083.2002.01149.x. PMID 12410796.
Kucharzik T, Gewirtz AT, Merlin D, et al. (2003). „Lateral membrane LXA4 receptors mediate LXA4's anti-inflammatory actions on intestinal epithelium.”. Am. J. Physiol., Cell Physiol. 284 (4): C888–96. DOI:10.1152/ajpcell.00507.2001. PMID 12456400.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMID 12477932.

Spoljašnje veze

„Formylpeptide Receptors: FPRL1”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2015-05-18.

Transmembranski receptor: G protein spregnuti receptori

Klasa A: Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Purinski	Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
Serotoninski	(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi	Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6) • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat

Peptid

Neuropeptidni

B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)

Drugi

Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)

Razno

Orfan	GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi	Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)

Klasa B: Sekretinu slični

Orfan

GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)

Drugi

Moždano specifični angiogenezni inhibitor (1, 2, 3) • Cadherin (1, 2, 3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1, 2) • EMR (1, 2, 3) • Glukagon (GR, GIPR, GLP1R, GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1, 2, 3, ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1, 2) • Sekretin • Vazoaktivni intestinalni peptid (1, 2)

Klasa C: Metabotropni
glutamat / feromon

Ukus	TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi	Kalcijum-detektujući receptor • GABA B (1, 2) • Glutamatni receptor (Metabotropni glutamat (1, 2, 3, 4, 5, 6, 7, 8)) • GPRC6A • GPR (156, 158, 179) • RAIG (1, 2, 3, 4)

Klasa F:
Frizzled / Zaglađeni

Uvojiti	Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni	Zaglađeni

B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

Vidi još

Reference

Literatura

Spoljašnje veze