Metroprolol (brand names Lopressor and Toprol XL) is a beta blocker medication used to:[1]
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Pronunciation | /mɛˈtoʊproʊlɑːl/, /mɛtoʊˈproʊlɑːl/ |
Trade names | Lopressor, Metolar XR, Toprol XL, others |
Synonyms | Lopressor |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682864 |
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Routes of administration | By mouth, intravenous |
Drug class | Beta blocker |
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Bioavailability | 50% (single dose)[2] 70% (repeated administration)[3] |
Protein binding | 12% |
Metabolism | Liver via CYP2D6, CYP3A4 |
Elimination half-life | 3–7 hours |
Excretion | Kidney |
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ECHA InfoCard | 100.051.952 |
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Chirality | Racemic mixture |
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Metoprolol was first made in 1969, patented in 1970, and approved for medical use in 1978.[4][5][6] It is on the World Health Organization's List of Essential Medicines.[7] It is available as a generic medication.[8] In 2021, it was the sixth most commonly prescribed medication in the United States, with more than 65 million prescriptions.[9][10][11]
Metoprolol is only available on prescription and it comes as tablets. It can also be given by injection, but this is usually done in hospital.[1]