Poisoning by ingestion, inhalation or absorption through the skin of BDF shows no signs or symptoms in humans other than delayed (after several days) development of severe, long-lasting (up to months) bleeding events. Consequently, victims may not suspect nor report exposure to BDF before overt bleeding is observed. Once manifested, bleeding is prolonged and can be fatal at high doses due to the long biological half-life of BDF which has been estimated to be over 90 days in serum, and almost 10 months in liver (Vandenbroucke et al., 2008), one of its main storage sites and where levels can reach 50-fold or greater than that in other tissues (Hauck et al., 2016). Importantly, BDF poisoning can be fatal if left untreated even at relatively small amounts (∼15 mg).[2]
Currently, although there exist means to attenuate the consequences of superwarfrain induced anti-coagulation, there are no FDA-approved drugs to eliminate BDF from tissues. Hence, various blood products and vitamin K1, an FDA-approved drug that increases vitamin K levels allowing activation of coagulation factors and provides anticoagulant effects throughout the body, are provided to patients until BDF no longer interferes with coagulation, a period which can extend for months, after which symptoms may reappear (Card et al., 2014, Underwood et al., 2014). However, since these treatments do not inactivate or eliminate BDF from the body, the long half-life (months) of BDF necessitates extended (months) courses of high-dose (up to 600 mg/day, 120 tablets) vitamin K supplementation which is very expensive (hundreds of US dollars per month) resulting in poor adherence by the patients.[2]
KETAMINE
For the functional group referred to as ketimine, see Imine.
Doubt onset
| Ketamine = bone fractures, analgesia, horses
| Wikipedia = [13], sinner B; ...
This article should be divided into sections by topic, to make it more accessible. Please help by adding section headings in accordance with Wikipedia's style guidelines.
I, the copyright holder of this work, hereby publish it under the following license:
Template:Cc-zero
HEART
I haven't gotten to thr heart yet, but
https://simple.m.wikipedia.org/wiki/Oedema
Mostly in thr legs when it is the heart, because of a specific chamber not working (i think it is the right side), but one side will cause other symptoms instead. It is a circulation issue. (TODO)
PREGNANCY
(Actually period pain (dysmenorrhoea))
References
↑
McKenna KA, Fogleman CD (August 2021). "Dysmenorrhea". Am Fam Physician. 104 (2): 164–170. PMID 34383437.
American College of Obstetricians and Gynecologists (Jan 2015). "FAQ046 Dynsmenorrhea: Painful Periods" (PDF). Archived (PDF) from the original on 27 June 2015. Retrieved 26 June 2015.
At one point the article the editor had the cause of death ranking wrong (and uses future predictions insread of past information). This is cited
Those are terrible bulletpoints which could be shortened down a lot. One of the bullet points I edited is the issue, which saw the whole article rolled back.
The "jargon" is used in brackets () with links to other wikipedia pages. This article rollback put information back in the article about the circulation which is wrong. W;ChangingUsername (talk) 18:03, 22 May 2024 (UTC)
Respectfully we're not a medical website, Anywho go to WP:Simple talk as others may disagree with me or may agree and either way will be able to help you better than I can, Thanks, –Davey2010Talk 18:07, 22 May 2024 (UTC)
And (reapectfully) the rules say the article needs to be written simply, not that it needs to be less detailed or cover information worse. Roll back your article properly if youre going to try and make it entirely your own
And the FAST memory aid should be remembered by everyone to help spot strokes.
W;ChangingUsername (talk) 18:19, 22 May 2024 (UTC)
Never once said it needs to be less detailed or cover worse information, I'm simply saying your edits aren't an improvement over what is there. Thanks. –Davey2010Talk 18:23, 22 May 2024 (UTC)
↑"Drug Scheduling". US DEA. Archived from the original on 8 April 2024. Retrieved 29 December 2023. ((cite web)): line feed character in |title= at position 5 (help) Ketamine is listed in Schedule III.
↑Huang, MC., Lin, SK. (2020). Ketamine Abuse: Past and Present. In: Hashimoto, K., Ide, S., Ikeda, K. (eds) Ketamine. Springer, Singapore. https://doi.org/10.1007/978-981-15-2902-3_1
↑Hijazi Y, Boulieu R (July 2002). "Contribution of CYP3A4, CYP2B6, and CYP2C9 isoforms to N-demethylation of ketamine in human liver microsomes". Drug Metabolism and Disposition. 30 (7): 853–8. doi:10.1124/dmd.30.7.853. PMID12065445. S2CID15787750.
↑Cite error: The named reference pmid27763887 was used but no text was provided for refs named (see the help page).