Receptor faktora rasta mastocita/matičnih ćelija (engl.Mast/stem cell growth factor receptor - SCFR), takođe poznat kao proto-onkogen c-Kit ili tirozinska proteinska kinaza Kit ili CD117, je protein koji je kod ljudi kodiran KITgenom.[1] Višestruke transkriptne varijante koje kodiraju različite izoforme ovog gena su poznate.[2] KIT prvi opisao nemački biohemičar Aksel Ulrič 1987. kao ćelijski homolog mačijeg sarkomnog viralnog onkogena v-kit.[3]
^Andre C, Hampe A, Lachaume P, Martin E, Wang XP, Manus V, Hu WX, Galibert F (1997). „Sequence analysis of two genomic regions containing the KIT and the FMS receptor tyrosine kinase genes”. Genomics. 39 (2): 216—26. PMID9027509. doi:10.1006/geno.1996.4482.
^ абвAnzai N, Lee Y, Youn BS, Fukuda S, Kim YJ, Mantel C, Akashi M, Broxmeyer HE (2002). „C-kit associated with the transmembrane 4 superfamily proteins constitutes a functionally distinct subunit in human hematopoietic progenitors”. Blood. 99 (12): 4413—21. PMID12036870. doi:10.1182/blood.V99.12.4413.
^ абLennartsson J, Wernstedt C, Engström U, Hellman U, Rönnstrand L (2003). „Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk”. Exp. Cell Res. 288 (1): 110—8. PMID12878163. doi:10.1016/S0014-4827(03)00206-4.
^ абvan Dijk TB, van Den Akker E, Amelsvoort MP, Mano H, Löwenberg B, von Lindern M (2000). „Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells”. Blood. 96 (10): 3406—13. PMID11071635.
^Sattler M, Salgia R, Shrikhande G, Verma S, Pisick E, Prasad KV, Griffin JD (1997). „Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)”. J. Biol. Chem. 272 (15): 10248—53. PMID9092574. doi:10.1074/jbc.272.15.10248.
^ абLiang X, Wisniewski D, Strife A, Shivakrupa, Clarkson B, Resh MD (2002). „Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling”. J. Biol. Chem. 277 (16): 13732—8. PMID11825908. doi:10.1074/jbc.M200277200.CS1 одржавање: Вишеструка имена: списак аутора (веза)
^ абVoisset E, Lopez S, Chaix A, Vita M, George C, Dubreuil P, De Sepulveda P (2010). „FES kinase participates in KIT-ligand induced chemotaxis”. Biochem. Biophys. Res. Commun. 393 (1): 174—8. PMID20117079. doi:10.1016/j.bbrc.2010.01.116.
^Feng GS, Ouyang YB, Hu DP, Shi ZQ, Gentz R, Ni J (1996). „Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway”. J. Biol. Chem. 271 (21): 12129—32. PMID8647802. doi:10.1074/jbc.271.21.12129.
^Lev S, Yarden Y, Givol D (1992). „A recombinant ectodomain of the receptor for the stem cell factor (SCF) retains ligand-induced receptor dimerization and antagonizes SCF-stimulated cellular responses”. J. Biol. Chem. 267 (15): 10866—73. PMID1375232.
^Blechman JM, Lev S, Brizzi MF, Leitner O, Pegoraro L, Givol D, Yarden Y (1993). „Soluble c-kit proteins and antireceptor monoclonal antibodies confine the binding site of the stem cell factor”. J. Biol. Chem. 268 (6): 4399—406. PMID7680037.
^Gueller S, Gery S, Nowak V, Liu L, Serve H, Koeffler HP (2008). „Adaptor protein Lnk associates with Tyr(568) in c-Kit”. Biochem. J. 415 (2): 241—5. PMID18588518. doi:10.1042/BJ20080102.
^Linnekin D, DeBerry CS, Mou S (1997). „Lyn associates with the juxtamembrane region of c-Kit and is activated by stem cell factor in hematopoietic cell lines and normal progenitor cells”. J. Biol. Chem. 272 (43): 27450—5. PMID9341198. doi:10.1074/jbc.272.43.27450.
^Jhun BH, Rivnay B, Price D, Avraham H (1995). „The MATK tyrosine kinase interacts in a specific and SH2-dependent manner with c-Kit”. J. Biol. Chem. 270 (16): 9661—6. PMID7536744. doi:10.1074/jbc.270.16.9661.
^Price DJ, Rivnay B, Fu Y, Jiang S, Avraham S, Avraham H (1997). „Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes”. J. Biol. Chem. 272 (9): 5915—20. PMID9038210. doi:10.1074/jbc.272.9.5915.
^Mancini A, Koch A, Stefan M, Niemann H, Tamura T (2000). „The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity”. FEBS Lett. 482 (1-2): 54—8. PMID11018522. doi:10.1016/S0014-5793(00)02036-6.
^Serve H, Hsu YC, Besmer P (1994). „Tyrosine residue 719 of the c-kit receptor is essential for binding of the P85 subunit of phosphatidylinositol (PI) 3-kinase and for c-kit-associated PI 3-kinase activity in COS-1 cells”. J. Biol. Chem. 269 (8): 6026—30. PMID7509796.
^Tauchi T, Feng GS, Marshall MS, Shen R, Mantel C, Pawson T, Broxmeyer HE (1994). „The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells”. J. Biol. Chem. 269 (40): 25206—11. PMID7523381.
^Bayle J, Letard S, Frank R, Dubreuil P, De Sepulveda P (2004). „Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling”. J. Biol. Chem. 279 (13): 12249—59. PMID14707129. doi:10.1074/jbc.M313381200.
^Lennartsson J, Blume-Jensen P, Hermanson M, Pontén E, Carlberg M, Rönnstrand L (1999). „Phosphorylation of Shc by Src family kinases is necessary for stem cell factor receptor/c-kit mediated activation of the Ras/MAP kinase pathway and c-fos induction”. Oncogene. 18 (40): 5546—53. PMID10523831. doi:10.1038/sj.onc.1202929.
Lennartsson J, Rönnstrand L (2006). „The stem cell factor receptor/c-Kit as a drug target in cancer”. Curr. Cancer Drug Targ. 6 (1): 65—75. PMID16475976. doi:10.2174/156800906775471725.
Rönnstrand L (2004). „Signal transduction via the stem cell factor receptor/c-Kit”. Cell. Mol. Life Sci. 61 (19–20): 2535—2548. PMID15526160. doi:10.1007/s00018-004-4189-6.
Linnekin D (2000). „Early signaling pathways activated by c-Kit in hematopoietic cells”. Int. J. Biochem. Cell Biol. 31 (10): 1053—74. PMID10582339. doi:10.1016/S1357-2725(99)00078-3.
Canonico B, Felici C, Papa S (2001). „CD117”. J. Biol. Regul. Homeost. Agents. 15 (1): 90—4. PMID11388751.
Valent P; Ghannadan M; Hauswirth AW; et al. (2003). „Signal transduction-associated and cell activation-linked antigens expressed in human mast cells”. Int. J. Hematol. 75 (4): 357—62. PMID12041664. doi:10.1007/BF02982124.
Sandberg AA, Bridge JA (2002). „Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors. gastrointestinal stromal tumors”. Cancer Genet. Cytogenet. 135 (1): 1—22. PMID12072198. doi:10.1016/S0165-4608(02)00546-0.
Larizza L, Magnani I, Beghini A (2005). „The Kasumi-1 cell line: a t(8;21)-kit mutant model for acute myeloid leukemia”. Leuk. Lymphoma. 46 (2): 247—55. PMID15621809. doi:10.1080/10428190400007565.
Miettinen M, Lasota J (2006). „KIT (CD117): a review on expression in normal and neoplastic tissues, and mutations and their clinicopathologic correlation”. Appl. Immunohistochem. Mol. Morphol. 13 (3): 205—20. PMID16082245.
Lasota J, Miettinen M (2007). „KIT and PDGFRA mutations in gastrointestinal stromal tumors (GISTs)”. Semin Diagn Pathol. 23 (2): 91—102. PMID17193822. doi:10.1053/j.semdp.2006.08.006.
Patnaik MM, Tefferi A, Pardanani A (2007). „Kit: molecule of interest for the diagnosis and treatment of mastocytosis and other neoplastic disorders”. Current cancer drug targets. 7 (5): 492—503. PMID17691909. doi:10.2174/156800907781386614.
Spritz RA, Droetto S, Fukushima Y (1992). „Deletion of the KIT and PDGFRA genes in a patient with piebaldism”. Am. J. Med. Genet. 44 (4): 492—5. PMID1279971. doi:10.1002/ajmg.1320440422.
Lev S, Yarden Y, Givol D (1992). „A recombinant ectodomain of the receptor for the stem cell factor (SCF) retains ligand-induced receptor dimerization and antagonizes SCF-stimulated cellular responses”. J. Biol. Chem. 267 (15): 10866—73. PMID1375232.
Alai M; Mui AL; Cutler RL; et al. (1992). „Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells”. J. Biol. Chem. 267 (25): 18021—5. PMID1381360.
Ashman LK; Cambareri AC; To LB; et al. (1991). „Expression of the YB5.B8 antigen (c-kit proto-oncogene product) in normal human bone marrow”. Blood. 78 (1): 30—7. PMID1712644.