Names | |
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Preferred IUPAC name
2-[(2-Cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole | |
Identifiers | |
3D model (JSmol)
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ChEMBL | |
ChemSpider | |
MeSH | Cirazoline |
PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C13H16N2O | |
Molar mass | 216.284 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Cirazoline is a full agonist at the α1A adrenergic receptor, a partial agonist at both the α1B and α1D adrenergic receptors,[1] and a nonselective antagonist to the α2 adrenergic receptor.[2] It is believed that this combination of properties could make cirazoline an effective vasoconstricting agent.[2]
Cirazoline has also been shown to decrease food intake in rats, purportedly through activation of α1 adrenoceptors in the paraventricular nucleus in the hypothalamus of the brain.[3] Administration of cirazoline also seemed to present impairment in the spatial memory of monkeys through the activation of the same receptors that showed decreased food intake in rats.[4][5] However, in preliminary studies, through stimulation of α2 adrenoceptors, working memory is comparatively improved.[4]