The contents of the Clotting factors page were merged into Coagulation on 3 September 2023. For the contribution history and old versions of the redirected page, please see its history; for the discussion at that location, see its talk page. |
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in the movie Resident Evil (2002), Matt Adison points out that a woman's blood has coagulated, pointing out it's impossible because blood only coagulates after death. One; blood coagulates all the time, not only after death. And two, how can you tell by looking at blood to see if it coagulated? —Preceding unsigned comment added by Blindy me (talk • contribs) 23:33, 15 September 2008 (UTC)
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In the event of copmlete integumentary deprivation, assuming you lived, would your skin scab over, or would something else happen? Razor Rozar7 (talk) 19:20, 7 May 2008 (UTC)
As a non-biologist, what this article doesn't tell me is how exposure to air makes platelets stick together, which is perhaps what coagulation is all about.
What it needs is something like "when factor blah on the surface of the platelet or in the blood comes into contact with air/oxygen/nitrogen/knives/blunt_objects is it suppressed/enhanced/confused/enlightened which triggers the cycle". I'm guessing that all these factors are also expressed on the surface of the platelet? Or are they inside? A chatty intro to the subject before the factor X does whatever to factor XI would help. - (unsigned)
I know the wikipedia's not a dictionary; but I still feel it's important not to suggest to a user who stumbles onto the page that coagulation is a technical term. Clearly it is in a medical context, but it's also just a plain old word in the English language. Hence the little disclaimer I added at the top of the page. I also specified that the article is about human blood, since it makes reference to specific clotting factors, genetic diseases, etc. I assume that the coagulation of blood in other animals follows a similar process — indeed, I'd bet my shirt on it — but I feel a little weird adding my own uninformed assumptions to a medical article so I'll just put this sentence here, which was once the last sentence of my disclaimer: The blood of other animals clots in similar ways. Please, somebody who can actually say this based on personal knowledge, add it back in again! Doops 21:43, 30 May 2004
it appears to me that this page is improperly titled. i suggest:
1) we make coagulation a disambig page with links to human blood coag as well as other types of coag like eggs + chinese food.
2) we move the material on this page to Coagulation of human blood.
Thoughts? Ungtss 16:42, 20 Apr 2005 (UTC)
HEY, WHAT ABOUT CONSENSUS FOR A MOVE? JFW | T@lk 23:19, 20 Apr 2005 (UTC)
I've reversed your move (which affects 100s of links). If you are unhappy with the present results, please allow a bit more time for consensus. JFW | T@lk 23:26, 20 Apr 2005 (UTC)
Can you agree to the present arrangement? JFW | T@lk 01:11, 21 Apr 2005 (UTC)
Do you have material that would be useful in a general way? Coagulation is not a phase in the way freezing or thawing is. It means widely different things in widely different contexts. Show us how you would generalise the entire concept of coagulation. JFW | T@lk 16:16, 27 July 2007 (UTC)
I haven't been actively involved with Wikipedia logistics in a while, but what is the criteria between showing a disambig page first vs. going to a default article? Is blood coagulation being "the most important form" one of the criteria? In that case, it would seem that Cricket should direct to the insect, which I'm pretty sure is indispensable to the ecosystem, rather than the sport. -- Bubbachuck (talk) 20:46, 12 April 2009 (UTC)
Since the moving of this article from the specific "coagulation of human blood" to the general "coagulation" it has become important to include disclaimers and disambiguations. Two thoughts about these:
(In general, indeed, this article — like so many scientific ones — assumes too much of the reader.) Doops 16:48, 21 Apr 2005 (UTC)
Most studies on coagulation of blood have been done in humans and small rodents. It is a highly conserved process in evolution, so there is a lot to be said about coagulation in other species. I suspect we'll need a separate paragraph on it, which identifies the exceptions rather than the similarities. JFW | T@lk 16:16, 27 July 2007 (UTC)
Would be great to have written which chromosomes code for different factors. --Eleassar777 13:49, 19 May 2005 (UTC)
as i recently have learned, the coagulation cascade is somewhat misleading in how the reactions occour. also im under the impression that the current scientist are commonly accepting this model instead of the old one from 1964.
more specifically, the order in which these reactions occour. i suggest interested ppl to read reviews by M hoffman and som from Nature to get a detailed description of how it works:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16131441&query_hl=22 http://www.nature.com/nrd/journal/v3/n8/abs/nrd1443_fs.html
Anyway the coagulation cascade fails to explain why for instance people with FXII deficiency do not have any bleeding disorders whatsoever, although it lies at the top of the cascade. Furthermore, the cascade fails to explain why FVIII from the intrinsic pathway causes heavy bleading disorders when it clearly shows that Thrombin can be produced from the extrinsic pathway alone.
shortly the cell mediated model is divided in three parts: initiation, amplification and propagation.
comments anyone???
Broccolee-
hmmm... so does that mean that the cell-mediated model is not fully accepted among scientists, or that the system is not yet fully understood? because from what i have read the new model makes complete sense. anyway, yeah the system is complex. still, if the other one is more correct it ought to be changed?
Don't know if anyone cares but as of 2010 all medical students at one of the large London medical schools are taught that the old intrinsic/extrinsic model is an old fallacy and are only being taught the cell based model. —Preceding unsigned comment added by 93.96.145.241 (talk) 10:14, 25 July 2010 (UTC)
A cell based model is now used to explain the coagulation process in most of the standard Hematology textbooks. So I guess it is high time this gets updated on this page. Angunnu (talk) 06:48, 30 October 2019 (UTC)
I just wikified and largely rewrote a stub article on thromboelastography (and learned a lot in the process), but I'm not sure where in this article it should be linked. Could those in the know please review my work, and add useful links to it from other articles? — Catherine\talk 18:44, 7 December 2005 (UTC)
Hi chaps,
Playing the random 10 articles game, I found this article. It appears to be nothing more than a copy and paste from Clotting_cascade#The_coagulation_cascade (ie, this page). It would be great if someone could be bold and decide whether the section merits its own page. If so, the material should probably be removed from this page with a link to that one, and it should be seriously wikified and contextified.
If not, the other page should be replaced with a redirect to this one (and there is one page linking to that page - please fix its link).
Thanks, pfctdayelise 14:12, 8 December 2005 (UTC)
I don't think the sentence "The use of adsorbent chemicals, such as zeolite, and other haemostatic agents is also being explored for use in sealing severe injuries quickly." really belongs in the intro. I am not sure if it even belongs to this page at all. Maybe we need a page Treatments for severe bleeding or something along those lines. I didn't make the edit since I didn't want to just remove the info without having anywhere else to put it.
Thanks, Azad 15:05, 28 January 2006 (UTC)
The coagulation cascade of secondary hemostasis has two pathways, the Contact Activation pathway (formally known as the Intrinsic Pathway) and the Tissue Factor pathway (formally known as the Extrinsic pathway) that lead to fibrin formation.
Do you mean formally as in 'the Contact Activation pathway is not an official term, it is informal', or actually 'formerly' as in 'used to be called'? Adam
Hi ppl , just as a quick comment, i though it was spelt HOMEOSTASIS not haemostasis.
thanks
I know that this page is about coagulation, which is not exactly the same thing as hemostasis, but the article does describe primary and secondary hemostasis (of which the coagulation cascade is a huge part). In that description, platelet aggregation is listed as the first step in primary hemostasis, but I was under the impression that vasoconstriction happens before that... LanceVictor 16:39, 25 March 2006 (UTC)
I think the diagram is misleading - in the coag cascade, Factor XIIa activates Factor XI to Factor XIa. If the arrows were flipped so that the middle curved bit was at Factor XIIa and the beginning of the arrow was at FXI and the end at FXIa, this would make more sense. Also this diagram is confusing as it mixes what happens in a test tube and what occurs in vivo. In vivo FXII is not part of coagulation, but is involved in fibrinolysis - the process by which the clot is removed.81.179.23.120 17:08, 5 July 2006 (UTC)CJ
Yes, the diagram is drawn improperly. The activated factors should be placed near the middle of the arrow representing the next step in the cascade. AAMiller 07:51, 6 March 2007 (UTC)
I wish you'd waited for discussion before removing the diagram that took me a lot of time to draw (:-$). The new one has similar weaknesses to my original one. JFW | T@lk 23:23, 23 April 2007 (UTC)
Joe, you're correct. I was just somewhat peeved that my diagram had been replaced :-). I've reinserted yours, which is much better than the one I drew in 2004. In particular, your diagram indicates the new link between thrombin and factor XI, which is in accordance with new paradigms on continuous thrombin generation vs thrombin burst.
As you may have seen, I'm updating the article quite heavily. Your assistance is very much appreciated, particularly in finding the right sources for things that I haven't sourced well at present. JFW | T@lk 20:11, 24 April 2007 (UTC)
Could there be a way to represent the magnitude of the clotting factors using broader arrow size and different font sizes. For example a particular factor might be present at low levels (small font) but can amplify greatly (represent with arrow that begins small but swells to its arrow head). This might provide an intuitive view of why some coagulation factors are indispensible while others can be compensated for. doctorwolfie 16:50, 29 August 2007 (UTC)
What software program was used in creating that coagulation cascade diagram? It looks great!! Ld99 (talk) 03:32, 6 December 2009 (UTC)
This diagram was recently replaced with a simplified version that lacks any of the feedback mechanisms. I think the previous graph was much more informative and should be restored. — Preceding unsigned comment added by 128.205.83.192 (talk) 18:18, 25 June 2012 (UTC)
Only today I discovered there is actually a comprehensive primary text about the history of coagulation. ISBN 1893005909 has a 400 page historical overview of all the characters. It is expensive (Amazon 2nd hand $250) but perhaps my library can order it from the British Library. JFW | T@lk 16:02, 12 September 2006 (UTC)
No luck yet. I've found some more historical material (S.I. Rapaport's historical overview in West J Med 1993) but I have no access to earlier theories. What is interesting is that for practical purposes the ancient Jews knew that stirring blood kept it liquid, as done in the sacrificial service in the Temple in Jerusalem. JFW | T@lk 14:59, 10 June 2007 (UTC)
This is the first Wikipedia article I've ever tried to read that seemed difficult for non-experts to understand. The theories of special relativity and quantum mechanics are mind-bending for most educated people, however, I find their Wikipedia articles easier to follow than this.
This article appears to be a very extensively documented and carefully (even lovingly) composed and edited article. Perhaps the same editors could step back and try to either write a layman's section or else water the technical language down a bit for the rest of us. The "Make Technical Articles Accessible" guideline has good material on how to approach this issue. --A. B. (talk) 22:31, 28 January 2007 (UTC)
I want to second the comment that this is too technical for the general audience of wikipedia. Personally, I think it's *WAAAAY* too technical. Cazort (talk) 01:08, 22 April 2008 (UTC)
I was wondering whether it would be worth having a simple summary near the top for us laymen before diving into the details? I did take AS biology some years ago but the article is still a bit of a tough read...
What I understand from the article without a thorough reading (I was a little putoff but the sheer complexity of the process):
The first hemostasis is that the platelets are activated by and stick to collagen fibres. (They are found outside the blood vessel?) The platelets then release the granules inside them, which ativates other platelets. eerr... so the effect is that they clump together at the wound? (is this a 'haemeostatic plug'?
(this bit I recall from distant memory...) Then the second hemostasis: by a complex chemical process the fibrinogen (soluble) is transformed into fibrin (insoluble). So now the fibrin helps block up the remain gaps and dams the flow of blood.
I guess that at the end of all that, the water evaporates causing the wet squidgy mass on the skin/floor/outside of the body to 'harden' and contract - simple loss of volume. I am actually observing the blood as I write :)
Is this very very crude summary even vaguely correct? 141.2.215.190 11:41, 6 March 2007 (UTC)
I'm editing the article to respond to concerns above. I've added some organisation and have expanded on topics such as pathology and pharmacology.
Any recommendations as to WP:RS? I found the Furie & Furie article, which looks pretty decent & may actually be counted as a source for many parts of the article. JFW | T@lk 01:23, 24 April 2007 (UTC)
This may become interesting: the plasma levels of clusters of coagulation factors seem to have a genetic basis: doi:10.1111/j.1538-7836.2007.02678.x JFW | T@lk 23:01, 2 July 2007 (UTC)
Shouldn't we include a scab photo? --Digitalgadget 18:14, 6 July 2007 (UTC)
This page is an exact copy of our article. I have asked the owners of the site to adhere to the GFDL when using Wikipedia content. JFW | T@lk 11:39, 25 November 2007 (UTC)
My dentist says clotting takes a quarter of an hour. True? There's nothing in the srticle about timing. --Guthrie (talk) 13:27, 16 July 2008 (UTC)
hi all
just a comment, although it has been mentioned correctly under (Physiology, The coagulation cascade) that the new pathways are in a 3 steps rather than as previously known intrensic and extrinsic pathways,but later on the explantion was in according to the old one..
thats why i think it should be modified.
thanks —Preceding unsigned comment added by 62.231.244.229 (talk) 11:18, 15 May 2010 (UTC)
Article requires modification in this aspect. vWF is not in the subendothelian layer, but is present in plasma, endothelian cells and trombocytes. The present statement is:
Damage to blood vessel walls exposes subendothelium proteins, most notably von Willebrand factor (vWF), present under the endothelium
Also citation is needed for most of the article — Preceding unsigned comment added by 130.243.248.155 (talk) 12:23, 4 December 2011 (UTC)
- vWF is in fact secreted into the subendothelial layer by endothelial cells. Source 69.80.36.114 (talk) 03:09, 30 November 2013 (UTC)
I was surprised to find myself on this page when I searched for "coagulation", since this such a specific instance of a pervasive phenomenon and it isn't a term I ever hear used to refer to blood clotting. I think "Blood clotting" is more natural, common, and recognizable, leaving "coagulation" to redirect to the general colloidal phenomenon (Flocculation). Jojalozzo 02:44, 25 March 2013 (UTC)
Extrinsic and intrinsic pathways theory is outdated. It reflects only the in-vitro overview of coagulation. In-vivo theory is based on Initiation, Amplification, Propagation and Localization. — Preceding unsigned comment added by Franzbischoff (talk • contribs) 14:36, 7 March 2014 (UTC)
Thrombogenesis is not a synonym for coagulation: Coagulation is a normal, appropriate, homeostatic and physiological response to injury resulting in attempted repair; while thrombogenesis is the initiation of an abnormal, pathological, disease state within a vessel resulting in partial to complete obstruction of blood flow. Pardon the redundant adjectives.
I'm going to delete the word, and if there is an objection, we can discuss it here.
```` — Preceding unsigned comment added by IiKkEe (talk • contribs) 01:37, 11 April 2014 (UTC)
The chart is somewhat outdated, in that it doe snot include HMWK and PK on the arrow from XII to XIIa; or HMWK and Ca++ on the arrow from XI to XIa; or that XI feeds back to XII and XII feeds back to the HMWK-PK complex; or that kallikrein (KK)activates XII.
There are more up to date charts out there (google coagulation cascade images) but I'm not enough of a computer person to know if permission is needed to import, how to get it if it is needed, and how to import. Anyone interested in pursuing this?
```` — Preceding unsigned comment added by IiKkEe (talk • contribs) 03:00, 11 April 2014 (UTC)
The new article covers the same topic Arthistorian1977 (talk) 20:11, 2 May 2015 (UTC)
Could somebody please explain me this step? (And maybe esplain it better in the article) --Impériale (talk) 20:44, 5 May 2015 (UTC)
I am going to make this very easy, not use medical terms and such. When there is a breach in your vessels you bleed. Obviously it has to be stopped. So there is a series of steps, much like a dance, which is swift and orderly if everything is in working order. In essence the coagulation cascade creates a "net" of fibrin. If all is working, the platelets do their bit - think of it as their developing protrusions on their exterior. The net catches on the protrusions, red cells get caught in the net, the final steps of the cascade take place and create a clot.
If anything is missing, too little, too much, out of step - disaster. Degree depending on what happens, at what point. Of course all is very much more complex and involves genetics as well as other aspects but you don't want to know any of that. Hope this helps.74.12.125.129 (talk)! —Preceding undated comment added 17:08, 9 April 2016 (UTC)
I'm having a difficult time understanding the transition in this paragraph after the second sentence. I am not sure why thrombin being present has to do with the separation of the coag cascade into two pathways. Is it saying that the classical separation into two pathways is not warranted since thrombin is already present? is it saying that one depends on the other one? I would like to see a better transition that unite the first and second paragraph. Thanks
Quote: The division of coagulation in two pathways is mainly artificial, it originates from laboratory tests in which clotting times were measured after the clotting was initiated by glass (intrinsic pathway) or by thromboplastin (a mix of tissue factor and phospholipids). In fact thrombin is present from the very beginning, already when platelets are making the plug. Thrombin has a large array of functions, not only the conversion of fibrinogen to fibrin, the building block of a hemostatic plug. In addition, it is the most impor...
Cleverwater (talk) 20:03, 20 March 2016 (UTC)
"Coagulation" is a more general term of colloid chemistry; though this page tells about only "Blood Coagulation", which is a specific sub-type of coagulation, and a complex process.
So please change the page name as Coagulation (Blood) or Coagulation of blood or Blood coagulation
Actually 2 alternative things could be done; however one of the following alternative will have massive side effects. So out of following two; I've chosen second one.
Option 1- Include the general aspect of coagulation of colloid chemistry. (And too, yet we don't have a single page on general aspect of coagulation; rather a lot of related fragmented page Flocculation,Particle aggregation,Syneresis (chemistry),Agglutination (biology) etc, lacking the whole picture about agglutination. The section Colloid#Destabilization (permalink) of page Colloid, containing the word coagulation, also gives very little place to elaborate about different aspects of coagulation)
Side effect- This will pressurize to reduce detailing on blood's Coagulation mechanism; that would be very bad. (So it is better to build a separate page for general aspects of coagulation without pressurizing this page)
Option-2- Let the page as it was- just change the name of the page as "Coagulation (Blood)" or "Coagulation of blood" or "blood coagulation".
Side effect- Pre-existing hyperlinks that was directed to page name "Coagulation", would become non-functional.
Solution- Not very difficult; building a new page with title "Coagulation (Blood)" (or "Coagulation of blood") and moving the content of this (currently "Coagulation" ) there; and thereafter leaving the page "Coagulation" as a redirect to new page "Coagulation (Blood)".
Now it depends on community.
RIT RAJARSHI (talk) 11:31, 9 August 2017 (UTC)
Figure 1 from this article seems like a good addition: https://ascpt.onlinelibrary.wiley.com/doi/full/10.1038/clpt.2009.87
UK BSH doi:10.1111/bjh.16776 JFW | T@lk 10:04, 30 October 2020 (UTC)
I propose merging Clotting factors into Coagulation, specifically in the 'List_of_coagulation_factors' section. The "Clotting Factors" page includes a table without additional context, and the information is mostly replicated on the "Coagulation" page, so there shouldn't be any issues. Significa liberdade (talk) 01:40, 30 July 2023 (UTC)